Fucoidans from Brown Seaweeds Sargassum hornery, Eclonia cava, Costaria costata: Structural Characteristics and Anticancer Activity

被引：166

作者：

Ermakova, Svetlana ^{[1
]}

Sokolova, Roza ^{[1
]}

Kim, Sang-Min ^{[2
]}

Um, Byung-Hun ^{[2
]}

Isakov, Vladimir ^{[1
]}

Zvyagintseva, Tatyana ^{[1
]}

机构：

[1] Russian Acad Sci, Far Eastern Branch, Pacific Inst Bioorgan Chem, Vladivostok 690022, Russia

[2] Korea Inst Sci & Technol, Kangnung 210340, South Korea

来源：

APPLIED BIOCHEMISTRY AND BIOTECHNOLOGY | 2011年 / 164卷 / 06期

关键词：

Fucoidans; Structure; Anticancer activity; POLYSACCHARIDES; ANTITUMOR; ALGA;

D O I：

10.1007/s12010-011-9178-2

中图分类号：

Q5 [生物化学]; Q7 [分子生物学];

学科分类号：

071010 ; 081704 ;

摘要：

Fucoidans were isolated by water extraction and ion-exchange chromatography from brown algae Eclonia cava, Sargassum hornery, and Costaria costata collected near of Korean coasts. The structures of fucoidans were investigated. Fucoidan from E. cava was mixture of sulfated rhamnogalactofucan and galactofucan. Fucoidan from C. costata was a sulfated galactofucan. Fucoidan isolated from S. hornery was separated into three fractions: a homofucan sulfate, a homofucan but without sulfate groups, and a sulfated rhamnofucan. The results clearly showed that fucoidans play an inhibitory role in colony formation in human melanoma and colon cancer cells and may be effective antitumor agents.

引用

页码：841 / 850

页数：10

共 17 条

[11] Fucoidan from Laminaria cichorioides inhibits AP-1 Transactivation and cell transformation in the mouse epidermal JB6 cells [J].