Animal models of nonalcoholic fatty liver disease/nonalcoholic steatohepatitis

被引：418
作者：
Takahashi, Yoshihisa [1 ]
Soejima, Yurie [1 ]
Fukusato, Toshio [1 ]
机构：
[1] Teikyo Univ, Sch Med, Dept Pathol, Itabashi Ku, Tokyo 1738605, Japan
来源：
WORLD JOURNAL OF GASTROENTEROLOGY | 2012年 / 18卷 / 19期
关键词：
Animal model; Nonalcoholic fatty liver disease; Nonalcoholic steatohepatitis; Metabolic syndrome; Histopathology; ACTIVATED-RECEPTOR-ALPHA; CHOLINE-DEFICIENT DIET; METHIONINE ADENOSYLTRANSFERASE 1A; FRUCTOSE-ENRICHED DIETS; INSULIN-RESISTANCE; METABOLIC SYNDROME; DB/DB MICE; HEPATIC INFLAMMATION; OXIDATIVE STRESS; NATURAL-HISTORY;
D O I：
10.3748/wjg.v18.i19.2300
中图分类号：
R57 [消化系及腹部疾病];
学科分类号：
摘要：
Nonalcoholic fatty liver disease (NAFLD) is a condition in which excess fat accumulates in the liver of a patient without a history of alcohol abuse. Nonalcoholic steatohepatitis (NASH), a severe form of NAFLD, can progress to liver cirrhosis and hepatocellular carcinoma. NAFLD is regarded as a hepatic manifestation of metabolic syndrome and incidence has been increasing worldwide in line with the increased prevalence of obesity, type 2 diabetes, and hyperlipemia. Animal models of NAFLD/NASH give crucial information, not only in elucidating pathogenesis of NAFLD/NASH but also in examining therapeutic effects of various agents. An ideal model of NAFLD/NASH should correctly reflect both hepatic histopathology and pathophysiology of human NAFLD/NASH. Animal models of NAFLD/NASH are divided into genetic, dietary, and combination models. In this paper, we review commonly used animal models of NAFLD/NASH referring to their advantages and disadvantages. (c) 2012 Baishideng. All rights reserved.
引用
收藏
页码：2300 / 2308
页数：9
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