Evaluation of recombinant interleukin-2 immunotherapy for human hemangiosarcoma in a SCID mice model (WB-SCID)

被引：13

作者：

Masuzawa, M ^{[1
]}

Mochida, N

Amano, T

Fujimura, T

Hamada, Y

Tamauchi, H

Sakurai, Y

Nishiyama, S

Katsuoka, K

机构：

[1] Kitasato Univ, Sch Med, Dept Dermatol, Sagamihara, Kanagawa 2288555, Japan

[2] Kitasato Univ, Sch Med, Dept Microbiol, Sagamihara, Kanagawa 2288555, Japan

[3] Kitasato Univ, Sch Allied Hlth Sci, Sagamihara, Kanagawa 2288555, Japan

来源：

JOURNAL OF DERMATOLOGICAL SCIENCE | 2001年 / 27卷 / 02期

关键词：

hemangiosarcoma; rIL-2; LAK; SCID mouse model WB-SCID;

D O I：

10.1016/S0923-1811(01)00103-7

中图分类号：

R75 [皮肤病学与性病学];

学科分类号：

100206 ;

摘要：

We treated the patients with cutaneous hemangiosarcoma with recombinant interleukin-2 (rIL-2) immunotherapy that showed clear therapeutic effects. This immunotherapy is popular for the treatment of hemangiosarcoma in Japan. The purpose of this study is to clarify the clinical effects in an animal experiment. After establishing a SCID mouse model of human hemangiosarcoma WB-SCID, we used this model to investigate anti-tumor effects of rIL-2 and LAK cells. We demonstrated that hemangiosarcoma cells are LAK-sensitive, and LAK cells induced by rIL-2 suppress the growth of hemangiosarcoma. Our results may assure the clinical effects of rIL-2 immunotherapy on hemangiosarcoma. (C) 2001 Elsevier Science Ireland Ltd. All rights reserved.

引用

页码：88 / 94

页数：7

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