Polyethylene Glycol (PEG-400) as an Efficient and Recyclable Reaction Medium for the One-Pot Synthesis of N-Substituted Azepines under Catalyst-Free Conditions

被引：14
|
作者：
Mallepalli, Raghu [2 ]
Yeramanchi, Lingappa [2 ]
Bantu, Rajashaker [1 ]
Nagarapu, Lingaiah [1 ]
机构：
[1] Indian Inst Chem Technol, Organ Chem Div 2, Hyderabad 500607, Andhra Pradesh, India
[2] Sri Venkateswara Univ, Dept Chem, Tirupati 517502, Andhra Pradesh, India
来源：
SYNLETT | 2011年 / 18期
关键词：
anilines; dialkylacetylene dicarboxylates; 2,5-dimethoxytetrahydrofuran; N-substituted azepines; polyethylene glycol; catalyst-free conditions; FALCIPARUM FOOD VACUOLE; ALPHA(2)-ADRENOCEPTOR; METHYLTRANSFERASE; PLASMEPSINS; INHIBITORS; SITE;
D O I：
10.1055/s-0031-1289542
中图分类号：
O62 [有机化学];
学科分类号：
070303 ; 081704 ;
摘要：
Polyethylene glycol (PEG) was found to be an inexpensive nontoxic and effective medium for the one-pot synthesis of N-substituted azepines under catalyst-free conditions in excellent yields. Environmental acceptability, low cost, high yields, and recyclability of the PEG are the important features of this protocol.
引用
收藏
页码：2730 / 2732
页数：3
相关论文
共 50 条
  • [1] Synthesis of α1-oxindole-α-hydroxyphosphonates under catalyst-free conditions using polyethylene glycol (PEG-400) as an efficient and recyclable reaction medium
    Nagarapu, Lingaiah
    Mallepalli, Raghu
    Kumar, U. Nikhil
    Venkateswarlu, P.
    Bantu, Rajashaker
    Yeramanchi, Lingappa
    TETRAHEDRON LETTERS, 2012, 53 (14) : 1699 - 1700
  • [2] Polyethylene glycol (PEG-400) promoted as an efficient and recyclable reaction medium for the one-pot eco-friendly synthesis of functionalized isoxazole substituted spirooxindole derivatives
    Modugu, Nagi Reddy
    Pittala, Praveen Kumar
    NEW JOURNAL OF CHEMISTRY, 2017, 41 (23) : 14062 - 14066
  • [3] PEG-400 promoted a simple, efficient, and recyclable catalyst for the one-pot eco-friendly synthesis of functionalized isoxazole substituted pyrroles in aqueous medium
    Ponduri, Rajasekhar
    Kumar, Pramod
    Vadali, Lakshmana Rao
    SYNTHETIC COMMUNICATIONS, 2018, 48 (24) : 3113 - 3122
  • [4] Polyethylene glycol (PEG-400) Mediated One-pot Green Synthesis of 4,7-Dihydro-2H-pyrazolo[3,4-b]pyridines Under Catalyst-free Conditions
    Kerru, Nagaraju
    Gummidi, Lalitha
    Maddila, Suresh
    Jonnalagadda, Sreekantha B.
    CHEMISTRYSELECT, 2020, 5 (40): : 12407 - 12410
  • [5] Efficient one-pot cascade synthesis of pyrazolopyridazine in PEG-400
    Gayake, Ranjit A.
    Jagrut, Vasant B.
    Humne, Vivek T.
    ORGANIC COMMUNICATIONS, 2022, 15 (03) : 297 - 303
  • [6] Polyethylene glycol (PEG-400): an efficient and recyclable reaction medium for the synthesis of pyrazolo[3,4-b]quinoline derivatives
    Karnakar, K.
    Murthy, S. Narayana
    Ramesh, K.
    Satish, G.
    Nanubolu, Jagadeesh Babu
    Nageswar, Y. V. D.
    TETRAHEDRON LETTERS, 2012, 53 (23) : 2897 - 2903
  • [7] Polyethylene glycol (PEG-400): An efficient and recyclable reaction medium for the synthesis of novel 1, 5-benzodiazepines and their antimicrobial activity
    Konda, Shankaraiah G.
    Shaikh, Baseer M.
    Chavan, Sanjay A.
    Dawane, Bhaskar S.
    CHINESE CHEMICAL LETTERS, 2011, 22 (01) : 65 - 68
  • [8] Polyethylene glycol (PEG-400): a mild and efficient reaction medium for one-pot synthesis of 3-hydroxy-3-(pyridin-2-ylmethyl)indolin-2-ones
    Raghu, M.
    Rajasekhar, M.
    Reddy, B. Chandra Obula
    Reddy, C. Suresh
    Reddy, B. V. Subba
    TETRAHEDRON LETTERS, 2013, 54 (27) : 3503 - 3506
  • [9] An efficient, one-pot synthesis of spiro[dihydropyridine-oxindole] compounds under catalyst-free conditions
    Lu, Guo-ping
    Cai, Chun
    JOURNAL OF CHEMICAL RESEARCH, 2011, (09) : 547 - 551
  • [10] PEG-400 remarkably efficient and recyclable media for one-pot synthesis of various 2-amino-4H-chromenes
    Shitole, Nana V.
    Shelke, Kiran F.
    Sadaphal, Sandip A.
    Shingate, Bapurao B.
    Shingare, Murlidhar S.
    GREEN CHEMISTRY LETTERS AND REVIEWS, 2010, 3 (02) : 83 - 87
12345