Self-assembling cashew gum-graft-polylactide copolymer nanoparticles as a potential amphotericin B delivery matrix

被引：22
作者：
Richter, Ana Rosa [1 ]
Carneiro, Maria J. [1 ]
de Sousa, Nayara A. [2 ]
Pinto, Vicente P. T. [2 ]
Freire, Rosimeyre S. [3 ]
de Sousa, Jeanlex S. [3 ]
Mendes, Josilayne F. S. [4 ]
Fontenelle, Raquel O. S. [4 ]
Feitosa, Judith P. A. [1 ]
Paula, Haroldo C. B. [1 ]
Goycoolea, Francisco M. [5 ]
de Paula, Regina C. M. [1 ]
机构：
[1] UFC CEP, Dept Organ & Inorgan Chem, Caixa Postal 6021,Humberto Monte S-N,Campus Pici, Fortaleza 60455760, Ceara, Brazil
[2] UFC, Fac Med, Comandante Mauro Celio Rocha Pontes 100, Derby CEP 6204228, Sobral, Brazil
[3] Univ Fed Ceara, Dept Phys, Fortaleza, Ceara, Brazil
[4] Univ Estadual Vale Acarau, Ctr Ciencias Agr & Biol, Curso Ciencias Biol, Sobral, Brazil
[5] Univ Leeds, Sch Food Sci & Nutr, Leeds LS16 7PA, W Yorkshire, England
来源：
INTERNATIONAL JOURNAL OF BIOLOGICAL MACROMOLECULES | 2020年 / 152卷
关键词：
Poly(lactic acid); Cashew gum; Nanoparticles; Amphotericin B; Antifungal activity; DRUG-RELEASE; EXUDATE POLYSACCHARIDE; SULFATE COPOLYMER; TREE GUM; ENCAPSULATION; DEGRADATION; CHITOSAN; ACRYLAMIDE; CELLULOSE; STATE;
D O I：
10.1016/j.ijbiomac.2020.02.166
中图分类号：
Q5 [生物化学]; Q7 [分子生物学];
学科分类号：
071010 ; 081704 ;
摘要：
Amphotericin B is an antibiotic used in the treatment of fungal disease and leishmania; however, it exhibits side effects to patients, hindering its wider application. Therefore, nanocarriers have been investigated as delivery systems for amphotericin B (AMB) in order to decrease its toxicity, besides increase bioavailability and solubility. Amphiphilic copolymers are interesting materials to encapsulate hydrophobic drugs such as AMB, hence copolymers of cashew gum (CG) and 1,1actide (LA) were synthesized using two different CG:LA molar ratios (1:1 and 1:10). Data obtained revealed that copolymer nanopartides present similar figures for particle sizes and zeta potentials; however, particle size of encapsulated AMB increases if compared to unloaded nanoparticles. The 1:10 nanoparticle sample has better stability although higher polydispersity index (PM) if compared to 1:1 sample. High amphotericin (AMB) encapsulation efficiencies and low hemolysis were obtained. AMB loaded copolymers show lower aggregation pattern than commercial AMB solution. AMB loaded nanoparticles show antifungal activities against four C. albicans strains. It can be inferred that cashew gum/polylactide copolymers have potential as nanocanier systems for AMB. (C) 2020 Elsevier B.V. All rights reserved.
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页码：492 / 502
页数：11
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