Field evaluation of five rapid diagnostic tests for screening of HIV-1 infections in rural Rakai, Uganda

被引：33

作者：

Kagulire, S. C. ^{[7
]}

Opendi, P. ^{[7
]}

Stamper, P. D. ^{[5
,6
]}

Nakavuma, J. L. ^{[4
]}

Mills, L. A. ^{[6
,7
]}

Makumbi, F. ^{[3
,7
]}

Gray, R. H. ^{[5
]}

Shott, J. P. ^{[1
,2
]}

Serwadda, D. ^{[3
]}

Reynolds, S. J. ^{[1
]}

机构：

[1] NIAID, NIH, Bethesda, MD 20892 USA

[2] NCI, Clin Monitoring Res Program, SAIC Frederick Inc, Frederick, MD 21701 USA

[3] Makerere Univ, Sch Publ Hlth, Kampala, Uganda

[4] Makerere Univ, Fac Vet Med, Kampala, Uganda

[5] Johns Hopkins Univ, Bloomberg Sch Publ Hlth, Baltimore, MD USA

[6] Johns Hopkins Univ, Sch Med, Baltimore, MD USA

[7] Rakai Hlth Sci Program, Kalisizo, Uganda

来源：

INTERNATIONAL JOURNAL OF STD & AIDS | 2011年 / 22卷 / 06期

基金：

美国国家卫生研究院;

关键词：

HIV; rapid diagnostic testing; Uganda; point of care tests; resource-poor settings;

D O I：

10.1258/ijsa.2009.009352

中图分类号：

R392 [医学免疫学]; Q939.91 [免疫学];

学科分类号：

100102 ;

摘要：

The performance characteristics of HIV rapid diagnostic tests (RDTs) vary by test and by population. We assessed five commercial RDTs in Uganda where all but one RDT (Determine; Abbott Laboratories, Germany) performed close to manufacturer's expectations. Determine had low specificity (85.2%, positive predictive value 67.3%) due to false-positive results with weak-positive bands. Properly trained staff, good quality control programmes and validation of RDTs with laboratories having confirmatory testing capacity may be warranted to assure accuracy in each setting.

引用

页码：308 / 309

页数：2

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