Cell death pathology: Perspective for human diseases

被引：43
作者：
Agostini, Massimiliano [1 ]
Tucci, Paola [2 ,3 ]
Melino, Gerry [2 ,3 ]
机构：
[1] Univ Leicester, Vled Res Council, Toxicol Unit, MRC, Leicester LE1 9HN, Leics, England
[2] Univ Roma Tor Vergata, Biochem IDI IRCCS Lab, I-00133 Rome, Italy
[3] Univ Roma Tor Vergata, Dept Expt Med, I-00133 Rome, Italy
来源：
BIOCHEMICAL AND BIOPHYSICAL RESEARCH COMMUNICATIONS | 2011年 / 414卷 / 03期
基金：
英国医学研究理事会;
关键词：
Apoptosis; Cancer; Neurodegenerative diseases; Immune system; AIDS; P73 INDUCES APOPTOSIS; AMYLOID BETA-PEPTIDE; PARKINSON-DISEASE; ALZHEIMER-DISEASE; NEUROFIBRILLARY TANGLES; 14-3-3; PROTEINS; ACTIVATION; AUTOPHAGY; RESISTANCE; P53;
D O I：
10.1016/j.bbrc.2011.09.081
中图分类号：
Q5 [生物化学]; Q7 [分子生物学];
学科分类号：
071010 ; 081704 ;
摘要：
Apoptosis, a genetically regulated form of cell death with distinct biochemical and morphological features, plays a relevant physiological and pathological role in the organism, being pivotal in the maintenance of tissue development and homeostasis in the adult as well as in the regulation of immune responses. Deregulation of this process causes several human disorders including cancer, autoimmune and neurodegenerative diseases. Thus, modulation of the apoptotic process and of cell death in general, is a potential therapeutic approach for the treatment of several human pathologies. (C) 2011 Elsevier Inc. All rights reserved.
引用
收藏
页码：451 / 455
页数：5
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