Regulation of Breast Cancer Progression by Extracellular Matrix Mechanics: Insights from 3D Culture Models

被引：27

作者：

Lee, Joanna Y. ^{[1
]}

Chaudhuri, Ovijit ^{[1
]}

机构：

[1] Stanford Univ, Dept Mech Engn, 452 Escondido Mall,Bldg 520,Room 226, Stanford, CA 94305 USA

来源：

ACS BIOMATERIALS SCIENCE & ENGINEERING | 2018年 / 4卷 / 02期

关键词：

biomaterials; hydrogels; extracellular matrix; stiffness; 3D culture; collagen; reconstituted basement membrane; CARCINOMA IN-SITU; EPITHELIAL-CELL LINE; GENE-EXPRESSION; MAMMARY-GLAND; 3-DIMENSIONAL CULTURE; MYOEPITHELIAL CELLS; COLLECTIVE INVASION; PHYSICAL-PROPERTIES; ALGINATE HYDROGELS; PROSTATE-CANCER;

D O I：

10.1021/acsbiomaterials.7b00071

中图分类号：

TB3 [工程材料学]; R318.08 [生物材料学];

学科分类号：

0805 ; 080501 ; 080502 ;

摘要：

There is increasing evidence that alteration in mechanical properties of the extracellular matrix (ECM) drives breast cancer progression, independent of genetic mutations. As such, how cells sense and respond to mechanical cues has become a critical area of study. Significant breakthroughs have been made using 3D culture systems that allow modeling of mammary epithelial cell (MEC) malignancy in vitro and advances in biomaterials that enable precise and independent manipulation of ECM mechanics. Here, we review the 3D materials systems that have pioneered MEC-ECM studies and innovations in engineered biomaterials that may advance the field of ECM-regulated breast cancer progression.

引用

页码：302 / 313

页数：12

共 137 条

[1] Human breast cancer invasion and aggression correlates with ECM stiffening and immune cell infiltration [J].

Acerbi, I. ;

Cassereau, L. ;

Dean, I. ;

Shi, Q. ;

Au, A. ;

Park, C. ;

Chen, Y. Y. ;

Liphardt, J. ;

Hwang, E. S. ;

Weaver, V. M. .

INTEGRATIVE BIOLOGY, 2015, 7 (10) :1120-1134

[2] The Role of Cancer-Associated Fibroblasts and Fibrosis in Liver Cancer [J].

Affo, Silvia ;

Yu, Le-Xing ;

Schwabe, Robert F. .

ANNUAL REVIEW OF PATHOLOGY: MECHANISMS OF DISEASE, VOL 12, 2017, 12 :153-186

[3] Mammographic density is related to stroma and stromal proteoglycan expression [J].

Alowami, S ;

Troup, S ;

Al-Haddad, S ;

Kirkpatrick, I ;

Watson, PH .

BREAST CANCER RESEARCH, 2003, 5 (05) :R129-R135

[4]

Andersen Therese, 2015, Microarrays (Basel), V4, P133, DOI 10.3390/microarrays4020133

[5] A Mechanical Checkpoint Controls Multicellular Growth through YAP/TAZ Regulation by Actin-Processing Factors [J].

Aragona, Mariaceleste ;

Panciera, Tito ;

Manfrin, Andrea ;

Giulitti, Stefano ;

Michielin, Federica ;

Elvassore, Nicola ;

Dupont, Sirio ;

Piccolo, Stefano .

CELL, 2013, 154 (05) :1047-1059

[6] Degradable Poly(2-hydroxyethyl methacrylate)-co-polycaprolactone Hydrogels for Tissue Engineering Scaffolds [J].

Atzet, Sarah ;

Curtin, Scott ;

Trinh, Phalen ;

Bryant, Stephanie ;

Ratner, Buddy .

BIOMACROMOLECULES, 2008, 9 (12) :3370-3377

[7] Hyaluronan in peritumoral stroma and malignant cells associates with breast cancer spreading and predicts survival [J].

Auvinen, P ;

Tammi, R ;

Parkkinen, J ;

Tammi, M ;

Ågren, U ;

Johansson, R ;

Hirvikoski, P ;

Eskelinen, M ;

Kosma, VM .

AMERICAN JOURNAL OF PATHOLOGY, 2000, 156 (02) :529-536

[8] The independent roles of mechanical, structural and adhesion characteristics of 3D hydrogels on the regulation of cancer invasion and dissemination [J].

Beck, Jennifer N. ;

Singh, Anirudha ;

Rothenberg, Ashley R. ;

Elisseeff, Jennifer H. ;

Ewald, Andrew J. .

BIOMATERIALS, 2013, 34 (37) :9486-9495

[9] Why don't we get more cancer? A proposed role of the microenvironment in restraining cancer progression [J].

Bissell, Mina J. ;

Hines, William C. .

NATURE MEDICINE, 2011, 17 (03) :320-329

[10] SUPPRESSION OF ICE AND APOPTOSIS IN MAMMARY EPITHELIAL-CELLS BY EXTRACELLULAR-MATRIX [J].

BOUDREAU, N ;

SYMPSON, CJ ;

WERB, Z ;

BISSELL, MJ .

SCIENCE, 1995, 267 (5199) :891-893

← 1 2 3 4 5 6 7 8 9 10 →