Total Synthesis of (+)-Daphmanidin E

被引：152

作者：

Weiss, Matthias E. ^{[1
]}

Carreira, Erick M. ^{[1
]}

机构：

[1] ETH, Organ Chem Lab, CH-8093 Zurich, Switzerland

来源：

ANGEWANDTE CHEMIE-INTERNATIONAL EDITION | 2011年 / 50卷 / 48期

关键词：

alkaloids; C-C coupling; cyclization; natural products; total synthesis; ASYMMETRIC CONJUGATE ADDITIONS; NATURAL PRODUCT SYNTHESIS; RADICAL REACTIONS; ORGANIC-SYNTHESIS; CYCLIZATION; ACID; CHEMISTRY; NITROALKENES; DERIVATIVES; ALKALOIDS;

D O I：

10.1002/anie.201104681

中图分类号：

O6 [化学];

学科分类号：

0703 ;

摘要：

From ring to ring: The first total synthesis of (+)-daphmanidinE features rapid access to an enantiomerically pure bicyclo[2.2.2]octadione and elaboration around its periphery through the implementation of two Claisen rearrangements, the use of a copper/peptide complex for reagent-controlled stereoselective conjugate addition, a diastereoselective hydroboration, and a cobalt-catalyzed alkyl-Heck cyclization. © 2011 WILEY-VCH Verlag GmbH & Co. KGaA, Weinheim.

引用

页码：11501 / 11505

页数：5

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