Phenotyping of P105-Negative B Cell Subsets in Patients with Systemic Lupus Erythematosus

被引：7

作者：

Koarada, Syuichi ^{[1
]}

Tada, Yoshifumi ^{[1
]}

Suematsu, Rie ^{[1
]}

Soejima, Sachiko ^{[1
]}

Inoue, Hisako ^{[1
]}

Ohta, Akihide ^{[2
]}

Nagasawa, Kohei ^{[1
]}

机构：

[1] Saga Univ, Fac Med, Div Rheumatol, Saga 8498501, Japan

[2] Saga Univ, Fac Med, Div Clin Nursing, Saga 8498501, Japan

来源：

CLINICAL & DEVELOPMENTAL IMMUNOLOGY | 2012年

关键词：

CD27(HIGH) PLASMA-CELLS; REVISED CRITERIA; DISEASE-ACTIVITY; CLASSIFICATION; EXPRESSION; ANTIBODY; RP105; CD27;

D O I：

10.1155/2012/198206

中图分类号：

R392 [医学免疫学]; Q939.91 [免疫学];

学科分类号：

100102 ;

摘要：

This study aimed to investigate phenotype of RP105(-) B cell subsets in patients with systemic lupus erythematosus (SLE). Flow cytometry was used for phenotyping RP105-negaive B cell subsets. Based on CD19, RP105, and CD138 expression, RP105(-) B cells consist of at least 5 subsets of late B cells, including CD19(+) RP105(int), CD19(+) RP105(-), CD19(low) RP105(-) CD138(-), CD19(low) RP105(-) CD138(int), and CD19(low) RP105(-) CD138(++) B cells. Especially, CD19(+) RP105(int) and CD19(low) RP105(-) CD138(int) B cells are significantly larger than other RP105(-) B cell subsets in SLE. By comparison of RP105(-) B cell subsets between patients with SLE and normal subjects, these subsets were detectable even in normal subjects, but the percentages of RP105(-) B cell subsets were significantly larger in SLE. The phenotypic analysis of RP105(-) B cell subsets suggests dysregulation of later B cell subsets in SLE and may provide new insights into understanding regulation of B cells in human SLE.

引用

页数：8

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