Gut Microbiota Interplay With COVID-19 Reveals Links to Host Lipid Metabolism Among Middle Eastern Populations

被引:27
作者
Al Bataineh, Mohammad Tahseen [1 ,2 ,3 ,4 ]
Henschel, Andreas [3 ,5 ]
Mousa, Mira [3 ,6 ]
Daou, Marianne [7 ]
Waasia, Fathimathuz [3 ]
Kannout, Hussein [3 ]
Khalili, Mariam [3 ]
Kayasseh, Mohd Azzam [8 ]
Alkhajeh, Abdulmajeed [9 ]
Uddin, Maimunah [10 ]
Alkaabi, Nawal [10 ]
Tay, Guan K. [11 ,12 ]
Feng, Samuel F. [3 ,13 ]
Yousef, Ahmed F. [7 ]
Alsafar, Habiba S. [3 ,13 ,14 ]
机构
[1] Univ Sharjah, Sharjah Inst Med Res, Sharjah, U Arab Emirates
[2] Univ Sharjah, Dept Clin Sci, Coll Med, Sharjah, U Arab Emirates
[3] Khalifa Univ Sci & Technol, Ctr Biotechnol, Abu Dhabi, U Arab Emirates
[4] Khalifa Univ Sci & Technol, Dept Genet & Mol Biol, Abu Dhabi, U Arab Emirates
[5] Khalifa Univ, Dept Elect Engn & Comp Sci, Abu Dhabi, U Arab Emirates
[6] Univ Oxford, Nuffield Dept Womens & Reprod Hlth, Oxford, England
[7] Khalifa Univ Sci & Technol, Dept Chem, Abu Dhabi, U Arab Emirates
[8] Emirates Specialty Hosp, Dubai Healthcare City, Dubai, U Arab Emirates
[9] Dubai Hlth Author, Med Educ & Res Dept, Dubai, U Arab Emirates
[10] Sheikh Khalifa Med City, Dept Pediat Infect Dis, Abu Dhabi, U Arab Emirates
[11] Univ Western Australia, Fac Hlth & Med Sci, Div Psychiat, Crawley, WA, Australia
[12] Edith Cowan Univ, Sch Med & Hlth Sci, Joondalup, WA, Australia
[13] Khalifa Univ Sci & Technol, Dept Math, Abu Dhabi, U Arab Emirates
[14] Khalifa Univ Sci & Technol, Dept Biomed Engn, Abu Dhabi, U Arab Emirates
关键词
COVID-19; glycerophospholipid; linoleic acid; microbiota; SARS-CoV-2;
D O I
10.3389/fmicb.2021.761067
中图分类号
Q93 [微生物学];
学科分类号
071005 ; 100705 ;
摘要
The interplay between the compositional changes in the gastrointestinal microbiome, severe acute respiratory syndrome coronavirus 2 (SARS-CoV-2) susceptibility and severity, and host functions is complex and yet to be fully understood. This study performed 16S rRNA gene-based microbial profiling of 143 subjects. We observed structural and compositional alterations in the gut microbiota of the SARS-CoV-2-infected group in comparison to non-infected controls. The gut microbiota composition of the SARS-CoV-2-infected individuals showed an increase in anti-inflammatory bacteria such as Faecalibacterium (p-value = 1.72 x 10(-6)) and Bacteroides (p-value = 5.67 x 10(-8)). We also revealed a higher relative abundance of the highly beneficial butyrate producers such as Anaerostipes (p-value = 1.75 x 10(-230)), Lachnospiraceae (p-value = 7.14 x 10(-65)), and Blautia (p-value = 9.22 x 10(-18)) in the SARS-CoV-2-infected group in comparison to the control group. Moreover, phylogenetic investigation of communities by reconstructing unobserved state (PICRUSt) functional prediction analysis of the 16S rRNA gene abundance data showed substantial differences in the enrichment of metabolic pathways such as lipid, amino acid, carbohydrate, and xenobiotic metabolism, in comparison between both groups. We discovered an enrichment of linoleic acid, ether lipid, glycerolipid, and glycerophospholipid metabolism in the SARS-CoV-2-infected group, suggesting a link to SARS-CoV-2 entry and replication in host cells. We estimate the major contributing genera to the four pathways to be Parabacteroides, Streptococcus, Dorea, and Blautia, respectively. The identified differences provide a new insight to enrich our understanding of SARS-CoV-2-related changes in gut microbiota, their metabolic capabilities, and potential screening biomarkers linked to COVID-19 disease severity.
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页数:11
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