Clinical course of neuropathologically confirmed frontal-variant Alzheimer's disease

被引：49
作者：
Taylor, Kirsten I.
Probst, Alphonse
Miserez, Andre R. [2 ]
Monsch, Andreas U.
Tolnay, Markus [1 ]
机构：
[1] Univ Basel Hosp, Dept Neuropathol, CH-4031 Basel, Switzerland
[2] Res Labs Diagene, Reinach, Switzerland
来源：
NATURE CLINICAL PRACTICE NEUROLOGY | 2008年 / 4卷 / 04期
关键词：
Alzheimer's disease; behavioral disturbances; cognitive functioning; frontal-variant Alzheimer's disease; frontal-variant frontotemporal dementia;
D O I：
10.1038/ncpneuro0746
中图分类号：
R74 [神经病学与精神病学];
学科分类号：
摘要：
Background A 66-year-old man presented with a 3-year history of personality changes marked by increasing apathy, social withdrawal and deficits in complex attention, and a 1-year history of progressive memory problems and difficulties in planning and carrying out complex tasks. Investigations Three neuropsychological examinations over 2 years, neurological examination, routine laboratory tests, brain MRI, single-photon emission CT scan, genetic analyses, and neuropathological examination. Diagnosis A clinical diagnosis of frontal-variant frontotemporal dementia was superseded by postmortem neuropathological evidence, which established a diagnosis of frontal-variant Alzheimer's disease. Management The patient and his spouse were referred for counseling, and the patient was referred for follow-up examinations.
引用
收藏
页码：226 / 232
页数：7
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