Cytotoxicity of some synthetic bis(arylidene) derivatives of cyclic ketones towards cisplatin-resistant human ovarian carcinoma cells

被引：4
作者：
Patel, Hinal [1 ]
Mothia, Begum [1 ]
Patel, Jaison [1 ]
Fasanya, Olatunde [1 ]
Sooda, Kartheek [2 ]
Javid, Farideh [2 ]
Wyatt, Peter B. [1 ]
机构：
[1] Queen Mary Univ London, Sch Biol & Chem Sci, Dept Chem, Joseph Priestley Bldg,Mile End Rd, London E1 4NS, England
[2] Univ Huddersfield, Sch Appl Sci, Dept Pharm, Huddersfield HD1 3DH, W Yorkshire, England
来源：
MEDICINAL CHEMISTRY RESEARCH | 2020年 / 29卷 / 06期
基金：
英国工程与自然科学研究理事会;
关键词：
Ovarian cancer; Dienone; Cytotoxicity; Curcumin; Carboplatin; Cisplatin; CURCUMIN ANALOGS; BIOLOGICAL EVALUATION; HIV-1; INTEGRASE; CANCER CELLS; INHIBITORS; APOPTOSIS; ARREST; DEATH;
D O I：
10.1007/s00044-020-02532-5
中图分类号：
R914 [药物化学];
学科分类号：
100701 ;
摘要：
Symmetrical alpha,alpha MODIFIER LETTER PRIME-bis(arylidene)ketones were prepared by acid-catalyzed aldol condensations between aliphatic ketones (e.g., cyclopentanone, 4-alkylcyclohexanones, tetrahydropyran-4-one, and tetrahydrothiopyran-4-one) and two equivalents of an aromatic hydroxyaldehyde (e.g., 4-hydroxybenzaldehyde, 3,4-dihydroxybenzaldehyde, vanillin, isovanillin, and 3-fluoro-4-hydroxybenzaldehyde). Most of the compounds were cytotoxic towards the cisplatin-resistant human ovarian cancer cell line A2780-CP70 as well as the non-resistant line A2780.
引用
收藏
页码：935 / 941
页数：7
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