Cytotoxicity of some synthetic bis(arylidene) derivatives of cyclic ketones towards cisplatin-resistant human ovarian carcinoma cells

被引：4

作者：

Patel, Hinal ^{[1
]}

Mothia, Begum ^{[1
]}

Patel, Jaison ^{[1
]}

Fasanya, Olatunde ^{[1
]}

Sooda, Kartheek ^{[2
]}

Javid, Farideh ^{[2
]}

Wyatt, Peter B. ^{[1
]}

机构：

[1] Queen Mary Univ London, Sch Biol & Chem Sci, Dept Chem, Joseph Priestley Bldg,Mile End Rd, London E1 4NS, England

[2] Univ Huddersfield, Sch Appl Sci, Dept Pharm, Huddersfield HD1 3DH, W Yorkshire, England

来源：

MEDICINAL CHEMISTRY RESEARCH | 2020年 / 29卷 / 06期

基金：

英国工程与自然科学研究理事会;

关键词：

Ovarian cancer; Dienone; Cytotoxicity; Curcumin; Carboplatin; Cisplatin; CURCUMIN ANALOGS; BIOLOGICAL EVALUATION; HIV-1; INTEGRASE; CANCER CELLS; INHIBITORS; APOPTOSIS; ARREST; DEATH;

D O I：

10.1007/s00044-020-02532-5

中图分类号：

R914 [药物化学];

学科分类号：

100701 ;

摘要：

Symmetrical alpha,alpha MODIFIER LETTER PRIME-bis(arylidene)ketones were prepared by acid-catalyzed aldol condensations between aliphatic ketones (e.g., cyclopentanone, 4-alkylcyclohexanones, tetrahydropyran-4-one, and tetrahydrothiopyran-4-one) and two equivalents of an aromatic hydroxyaldehyde (e.g., 4-hydroxybenzaldehyde, 3,4-dihydroxybenzaldehyde, vanillin, isovanillin, and 3-fluoro-4-hydroxybenzaldehyde). Most of the compounds were cytotoxic towards the cisplatin-resistant human ovarian cancer cell line A2780-CP70 as well as the non-resistant line A2780.

引用

页码：935 / 941

页数：7

共 18 条

[1] Synthesis and biological evaluation of novel curcumin analogs as anti-cancer and anti-angiogenesis agents
Adams, BK
Ferstl, EM
Davis, MC
Herold, M
Kurtkaya, S
Camalier, RF
Hollingshead, MG
Kaur, G
Sausville, EA
Rickles, FR
Snyder, JP
Liotta, DC
Shoji, M
[J]. BIOORGANIC & MEDICINAL CHEMISTRY, 2004, 12 (14) : 3871 - 3883
[2] Geometrically and conformationally restrained cinnamoyl compounds as inhibitors of HIV-1 integrase: Synthesis, biological evaluation, and molecular modeling
Artico, M
Di Santo, R
Costi, R
Novellino, E
Greco, G
Massa, S
Tramontano, E
Marongiu, ME
De Montis, A
La Colla, P
[J]. JOURNAL OF MEDICINAL CHEMISTRY, 1998, 41 (21) : 3948 - 3960
[3] Bairam R, 2017, INT J PHARM PHARM SC, V9, P233, DOI [10.22159/ijpps.2017v9i3.16406, DOI 10.22159/IJPPS.2017V9I3.16406]
[4] The BCL2 family: Regulators of the cellular life-or-death switch
Cory, S
Adams, JM
[J]. NATURE REVIEWS CANCER, 2002, 2 (09) : 647 - 656
[5] 2,6-Bis(3,4,5-trihydroxybenzylydene) derivatives of cyclohexanone: novel potent HIV-1 integrase inhibitors that prevent HIV-1 multiplication in cell-based assays
Costi, R
Di Santo, R
Artico, M
Massa, S
Ragno, R
Loddo, R
La Colla, M
Tramontano, E
La Colla, P
Pani, A
[J]. BIOORGANIC & MEDICINAL CHEMISTRY, 2004, 12 (01) : 199 - 215
[6] Potency of Michael reaction accepters as inducers of enzymes that protect against carcinogenesis depends on their reactivity with sulfhydryl groups
Dinkova-Kostova, AT
Massiah, MA
Bozak, RE
Hicks, RJ
Talalay, P
[J]. PROCEEDINGS OF THE NATIONAL ACADEMY OF SCIENCES OF THE UNITED STATES OF AMERICA, 2001, 98 (06) : 3404 - 3409
[7] Systems biology of cisplatin resistance: past, present and future
Galluzzi, L.
Vitale, I.
Michels, J.
Brenner, C.
Szabadkai, G.
Harel-Bellan, A.
Castedo, M.
Kroemer, G.
[J]. CELL DEATH & DISEASE, 2014, 5 : e1257 - e1257
[8] HAMAGUCHI K, 1993, CANCER RES, V53, P5225
[9] STRUCTURE AND ANTITUMOR ACTIVITY RELATIONSHIP OF 2-ARYLIDENE-4-CYCLOPENTENE-1,3-DIONES AND 2-ARYLIDENEINDAN-1,3-DIONES
INAYAMA, S
MAMOTO, K
SHIBATA, T
HIROSE, T
[J]. JOURNAL OF MEDICINAL CHEMISTRY, 1976, 19 (03) : 433 - 436
[10] Functionalized curcumin analogs as potent modulators of the Wnt/β-catenin signaling pathway
Leow, Pay-Chin
Bahety, Priti
Boon, Choon Pei
Lee, Chong Yew
Tan, Kheng Lin
Yang, Tianming
Ee, Pui-Lai Rachel
[J]. EUROPEAN JOURNAL OF MEDICINAL CHEMISTRY, 2014, 71 : 67 - 80

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