Intravenous Lidocaine Significantly Reduces the Propofol Dose in Elderly Patients Undergoing Gastroscopy: A Randomized Controlled Trial

被引：11

作者：

Hu, Song ^{[1
,2
,3
]}

Wang, Mingxia ^{[2
,3
]}

Li, Siyu

Zhou, Wenyu ^{[2
,3
]}

Zhang, Yi ^{[2
]}

Shi, Haobing ^{[2
]}

Ye, Pengcheng ^{[2
]}

Sun, Jixiong ^{[2
]}

Liu, Feng ^{[2
]}

Zhang, Wei ^{[2
]}

Zheng, Li ^{[3
]}

Hou, Qianhao ^{[2
]}

Wang, Yue ^{[2
]}

Sun, Weixin ^{[2
]}

Chen, Yuanli ^{[2
]}

Lu, Zhenzhen ^{[4
]}

Ji, Zhonghua ^{[2
]}

Liao, Lijun ^{[2
]}

Lv, Xin ^{[3
]}

Wang, Yinglin ^{[2
]}

Wang, Xiangrui ^{[2
,4
,5
]}

Yang, Hao ^{[3
,4
,5
]}

机构：

[1] Wannan Med Coll, Grad Sch, Wuhu 241002, Peoples R China

[2] Tongji Univ, Shanghai East Hosp, Dept Anesthesiol & Pain Management, Sch Med, Shanghai 200120, Peoples R China

[3] Tongji Univ, Shanghai Pulm Hosp, Dept Anesthesiol, Sch Med, Shanghai 200433, Peoples R China

[4] Fudan Univ, Zhongshan Hosp, Dept Biostat, Shanghai 200032, Peoples R China

[5] Tongji Univ, Shanghai East Hosp, Dept Anesthesiol & Pain Management, Sch Med, 150 Jimo Rd, Shanghai 200120, Peoples R China

来源：

DRUG DESIGN DEVELOPMENT AND THERAPY | 2022年 / 16卷

关键词：

lidocaine; propofol; gastroscopy; elderly patient; sedation; VENTILATORY RESPONSE; PROCEDURAL SEDATION; INFUSION; REQUIREMENTS; COLONOSCOPY; KETAMINE;

D O I：

10.2147/DDDT.S377237

中图分类号：

R914 [药物化学];

学科分类号：

100701 ;

摘要：

Objective: Propofol-based sedation has been widely used for gastroscopy, but the risk of respiratory suppression in elderly patients should not be overlooked. Intravenous (IV) lidocaine during surgery can reduce the demand for propofol and the incidence of cardiopulmonary complications. We examined whether IV lidocaine reduces the dose of propofol and the occurrence of adverse events during gastroscopy in elderly patients. Methods: We conducted a prospective, single-center, double-blind randomized controlled trial in elderly patients aged >= 65 years with ASA I-II. Subjects were randomly assigned to the lidocaine group (Group L, n=70), who received IV 1.5 mg kg-1 lidocaine followed by a continuous infusion of 4 mg kg-1 h-1 lidocaine, or the normal saline group (Group N, n=70), who received an equal volume of saline in the same way.Results: IV lidocaine reduced the total and maintenance propofol dose in Group L (p<0.001), with no significant effect on the induction dose. The incidence of intraoperative hypoxia (p=0.035), emergency airway management events (p=0.005), duration of gastroscopy (p<0.05), consciousness recovery time (p<0.001), and postoperative pain (p=0.009) were all reduced in Group L. Patient (p=0.025) and gastroscopist (p=0.031) satisfaction was higher in Group L. Intraoperative hemodynamic parameters, the respiratory rate, the incidence of sedation-related events and anesthesiologist satisfaction were similar between the two groups.Conclusion: IV lidocaine can significantly reduce the amount of propofol, the incidence of hypoxia and postoperative pain during gastroscopy in elderly patients, with a higher patient and gastroscopist satisfaction.

引用

页码：2695 / 2705

页数：11

共 35 条

[1] Intraoperative tissue oxygenation and postoperative outcomes after major non-cardiac surgery: an observational study [J].