Post-exposure prophylaxis for HIV infection

被引：0

作者：

Rey, David ^{[1
]}

机构：

[1] Hop Univ, NHC, Ctr Soins Infect VIH, F-67091 Strasbourg, France

来源：

EXPERT REVIEW OF ANTI-INFECTIVE THERAPY | 2011年 / 9卷 / 04期

关键词：

adherence; adverse events; antiretrovirals; cost-effectiveness; follow-up; HIV testing; lopinavir; post-exposure; prophylaxis; raltegravir; transmission risk; INJECTION-DRUG EXPOSURE; HEALTH-CARE WORKERS; OCCUPATIONAL-EXPOSURE; COST-EFFECTIVENESS; MALE CIRCUMCISION; SEXUAL TRANSMISSION; NEEDLESTICK INJURY; RISK BEHAVIORS; HOMOSEXUAL-MEN; NEVIRAPINE USE;

D O I：

10.1586/ERI.11.20

中图分类号：

R51 [传染病];

学科分类号：

100401 ;

摘要：

Post-exposure prophylaxis (PEP) with antiretrovirals is now widely used worldwide after either occupational contact (with blood or another blood-containing fluid), or nonoccupational contact (mainly sexual or injection-drug use). It is assumed to reduce the risk of HIV transmission by at least 80%, although its efficacy has not been completely proven. Several countries have issued guidelines to help the clinician in their decision to offer PEP and to improve its cost-effectiveness. This article reviews the different antiretroviral combinations used, their safety profile, the recommendations and indications of PEP. The initial evaluation of an exposed individual is presented, as well as the follow-up during and after treatment.

引用

页码：431 / 442

页数：12

共 80 条

[1] Survival of HIV-1 in syringes: Effects of temperature during storage [J].

Abdala, N ;

Reyes, R ;

Carney, JM ;

Heimer, R .

SUBSTANCE USE & MISUSE, 2000, 35 (10) :1369-1383

[2] Effectiveness and Safety of Tenofovir Gel, an Antiretroviral Microbicide, for the Prevention of HIV Infection in Women [J].

Karim, Quarraisha Abdool ;

Karim, Salim S. Abdool ;

Frohlich, Janet A. ;

Grobler, Anneke C. ;

Baxter, Cheryl ;

Mansoor, Leila E. ;

Kharsany, Ayesha B. M. ;

Sibeko, Sengeziwe ;

Mlisana, Koleka P. ;

Omar, Zaheen ;

Gengiah, Tanuja N. ;

Maarschalk, Silvia ;

Arulappan, Natasha ;

Mlotshwa, Mukelisiwe ;

Morris, Lynn ;

Taylor, Douglas .

SCIENCE, 2010, 329 (5996) :1168-1174

[3] Impact of telephonic psycho-social support on adherence to post-exposure prophylaxis (PEP) after rape [J].

Abrahams, Naeemah ;

Jewkes, Rachel ;

Lombard, Carl ;

Mathews, Shanaaz ;

Campbell, Jacquelyn ;

Meel, Banwari .

AIDS CARE-PSYCHOLOGICAL AND SOCIO-MEDICAL ASPECTS OF AIDS/HIV, 2010, 22 (10) :1173-1181

[4]

[Anonymous], 2009, AIDS EPIDEMIC UPDATE

[5] Randomized, controlled intervention trial of male circumcision for reduction of HIV infection risk: The ANRS 1265 trial [J].

Auvert, B ;

Taljaard, D ;

Lagarde, E ;

Sobngwi-Tambekou, J ;

Sitta, M ;

Puren, A .

PLOS MEDICINE, 2005, 2 (11) :1112-1122

[6] Occupational Risks and Hepatitis B Vaccination Status of Dental Auxiliaries in Nigeria [J].

Azodo, C. C. ;

Ehigiator, O. ;

Ojo, M. A. .

MEDICAL PRINCIPLES AND PRACTICE, 2010, 19 (05) :364-366

[7] Male circumcision for HIV prevention in young men in Kisumu, Kenya: a randomised controlled trial [J].

Bailey, Robert C. ;

Moses, Stephen ;

Parker, Corette B. ;

Agot, Kawango ;

Maclean, Ian ;

Krieger, John N. ;

Williams, Carolyn F. M. ;

Campbell, Richard T. ;

Ninya-Achola, Jeckoniah O. .

LANCET, 2007, 369 (9562) :643-656

[8] Postexposure prophylaxis for victims of sexual assault: treatments and attitudes of emergency department physicians [J].

Bakhru, Arvind ;

Mallinger, Julie B. ;

Fox, Michelle C. .

CONTRACEPTION, 2010, 82 (02) :168-173

[9] Expanded postexposure prophylaxis for simultaneous multiple source HIV exposure in a health-care worker [J].

Baraboutis, I. G. ;

Papastamopoulos, V. ;

Georgiou, O. ;

Samarkos, M. ;

Vrionis, E. ;

Kotsianopoulou, M. ;

Skoutelis, A. T. .

INTERNATIONAL JOURNAL OF STD & AIDS, 2010, 21 (02) :147-148

[10] Human bites: a rare risk factor for HIV transmission [J].

Bartholomew, CF ;

Jones, AM .

AIDS, 2006, 20 (04) :631-632

← 1 2 3 4 5 6 7 8 →