BMP signalling: agony and antagony in the family

被引：262

作者：

Brazil, Derek P. ^{[1
]}

Church, Rachel H. ^{[1
]}

Surae, Satnam ^{[2
]}

Godson, Catherine ^{[2
]}

Martin, Finian ^{[2
]}

机构：

[1] Queens Univ Belfast, Ctr Med Expt, Belfast BT12 6BA, Antrim, North Ireland

[2] Univ Coll Dublin, Conway Inst, Dublin 4, Ireland

来源：

TRENDS IN CELL BIOLOGY | 2015年 / 25卷 / 05期

基金：

英国生物技术与生命科学研究理事会; 爱尔兰科学基金会;

关键词：

bone morphogenetic proteins; antagonist; miRNA; Gremlin; disease; BONE MORPHOGENETIC PROTEIN; GROWTH-FACTOR-BETA; TO-MESENCHYMAL TRANSITION; SKELETAL-MUSCLE DIFFERENTIATION; KIELIN/CHORDIN-LIKE PROTEIN; GREMLIN-MEDIATED DECREASE; TGF-BETA; RENAL FIBROSIS; CELL-PROLIFERATION; EPITHELIAL-CELLS;

D O I：

10.1016/j.tcb.2014.12.004

中图分类号：

Q2 [细胞生物学];

学科分类号：

071009 ; 090102 ;

摘要：

Bone morphogenetic proteins (BMPs) are secreted extracellular matrix (ECM)-associated proteins that regulate a wide range of developmental processes, including limb and kidney formation. A critical element of BMP regulation is the presence of secreted antagonists that bind and inhibit BMP binding to their cognate Ser/Thr kinase receptors at the plasma membrane. Antagonists such as Noggin, Chordin, Gremlin (Grem1), and twisted gastrulation-1 (Twsg1) have been shown to inhibit BMP action in a range of different cell types and developmental stage-specific contexts. Here we review new developments in the field of BMP and BMP antagonist biology during mammalian development and suggest strategies for targeting these proteins in human disease.

引用

页码：249 / 264

页数：16

共 195 条

[1] MicroRNA-21 is an important downstream component of BMP signalling in epidermal keratinocytes [J].

Ahmed, Mohammed I. ;

Mardaryev, Andrei N. ;

Lewis, Christopher J. ;

Sharov, Andrey A. ;

Botchkareva, Natalia V. .

JOURNAL OF CELL SCIENCE, 2011, 124 (20) :3399-3404

[2] Quantitative kinetics analysis of BMP2 uptake into cells and its modulation by BMP antagonists [J].

Alborzinia, Hamed ;

Schmidt-Glenewinkel, Hannah ;

Ilkavets, Iryna ;

Breitkopf-Heinlein, Katja ;

Cheng, Xinlai ;

Hortschansky, Peter ;

Dooley, Steven ;

Woelfl, Stefan .

JOURNAL OF CELL SCIENCE, 2013, 126 (01) :117-127

[3] Bone morphogenetic proteins and their antagonists: current and emerging clinical uses [J].

Ali, Imran H. A. ;

Brazil, Derek P. .

BRITISH JOURNAL OF PHARMACOLOGY, 2014, 171 (15) :3620-3632

[4] Structure of the ternary signaling complex of a TGF-β superfamily member [J].

Allendorph, George P. ;

Vale, Wylie W. ;

Choe, Senyon .

PROCEEDINGS OF THE NATIONAL ACADEMY OF SCIENCES OF THE UNITED STATES OF AMERICA, 2006, 103 (20) :7643-7648

[5] Structural and Functional Insights into Endoglin Ligand Recognition and Binding [J].

Alt, Aaron ;

Miguel-Romero, Laura ;

Donderis, Jordi ;

Aristorena, Mikel ;

Blanco, Francisco J. ;

Round, Adam ;

Rubio, Vicente ;

Bernabeu, Carmelo ;

Marina, Alberto .

PLOS ONE, 2012, 7 (02)

[6] BMP6 is a key endogenous regulator of hepcidin expression and iron metabolism [J].

Andriopoulos, Billy, Jr. ;

Corradini, Elena ;

Xia, Yin ;

Faasse, Sarah A. ;

Chen, Shanzhuo ;

Grgurevic, Lovorka ;

Knutson, Mitchell D. ;

Pietrangelo, Antonello ;

Vukicevic, Slobodan ;

Lin, Herbert Y. ;

Babitt, Jodie L. .

NATURE GENETICS, 2009, 41 (04) :482-487

[7]

[Anonymous], ONCOGENE

[8] DMH1, a Novel BMP Small Molecule Inhibitor, Increases Cardiomyocyte Progenitors and Promotes Cardiac Differentiation in Mouse Embryonic Stem Cells [J].

Ao, Ada ;

Hao, Jijun ;

Hopkins, Corey R. ;

Hong, Charles C. .

PLOS ONE, 2012, 7 (07)

[9] Comparative genomic analysis of the eight-membered ring cystine knot-containing bone morphogenetic protein antagonists [J].

Avsian-Kretchmer, O ;

Hsueh, AJW .

MOLECULAR ENDOCRINOLOGY, 2004, 18 (01) :1-12

[10] Bone morphogenetic protein signaling by hemojuvelin regulates hepcidin expression [J].

Babitt, JL ;

Huang, FW ;

Wrighting, DM ;

Xia, Y ;

Sidis, Y ;

Samad, TA ;

Campagna, JA ;

Chung, RT ;

Schneyer, AL ;

Woolf, CJ ;

Andrews, NC ;

Lin, HY .

NATURE GENETICS, 2006, 38 (05) :531-539

← 1 2 3 4 5 6 7 8 9 10 →