Cell-transistor hybrid systems and their potential applications

被引：78

作者：

Offenhäusser, A ^{[1
]}

Knoll, W ^{[1
]}

机构：

[1] Max Planck Inst Polymer Res, D-55128 Mainz, Germany

来源：

TRENDS IN BIOTECHNOLOGY | 2001年 / 19卷 / 02期

关键词：

D O I：

10.1016/S0167-7799(00)01544-4

中图分类号：

Q81 [生物工程学（生物技术）]; Q93 [微生物学];

学科分类号：

071005 ; 0836 ; 090102 ; 100705 ;

摘要：

Electrogenic cells fire spontaneous or triggered action potentials (transient changes of their membrane potentials) and can be electronically coupled to external electrodes (arrays). Signals from rat heart-muscle cells were recorded by a field-effect transistor and the results described on the basis of an equivalent circuit. This technique has potential applications in drug screening. such as measuring the dose-response curve of isoproterenol, a beta -adrenergic agonist with a positive chronotropic effect.

引用

页码：62 / 66

页数：5

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