Cytotoxic diterpenoids and sesquiterpenoids from Pteris multifida

被引：64

作者：

Ge, Xin ^{[1
,2
]}

Ye, Guan ^{[1
]}

Li, Ping ^{[1
]}

Tang, Wen-Jie ^{[1
]}

Gao, Jin-Li ^{[1
]}

Zhao, Wei-Min ^{[2
]}

机构：

[1] Cent Res Inst Shanghai Pharmaceut Grp, Shanghai 201203, Peoples R China

[2] Chinese Acad Sci, Shanghai Inst Mat Med, Shanghai Inst Biol Sci, Shanghai 201203, Peoples R China

来源：

JOURNAL OF NATURAL PRODUCTS | 2008年 / 71卷 / 02期

关键词：

D O I：

10.1021/np0706421

中图分类号：

Q94 [植物学];

学科分类号：

071001 ;

摘要：

Three new ent-kaurane diterpenoids, named pterokaurane M-1-M-3 (1-3) and three new C-14 pterosin-sesquiterpenoids, named multifidoside A-C (4-6), along with 18 known compounds, were isolated from the whole plants of Pteris multifida. The structures of 1-6 were established using spectroscopic methods, including extensive 2D NMR and CD analyses. Compounds 4 and 5 showed cytotoxicity against the HepG2 tumor cell line with IC50 values of less than 10 mu M.

引用

页码：227 / 231

页数：5

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