Cytotoxic diterpenoids and sesquiterpenoids from Pteris multifida

被引:63
作者
Ge, Xin [1 ,2 ]
Ye, Guan [1 ]
Li, Ping [1 ]
Tang, Wen-Jie [1 ]
Gao, Jin-Li [1 ]
Zhao, Wei-Min [2 ]
机构
[1] Cent Res Inst Shanghai Pharmaceut Grp, Shanghai 201203, Peoples R China
[2] Chinese Acad Sci, Shanghai Inst Mat Med, Shanghai Inst Biol Sci, Shanghai 201203, Peoples R China
来源
JOURNAL OF NATURAL PRODUCTS | 2008年 / 71卷 / 02期
关键词
D O I
10.1021/np0706421
中图分类号
Q94 [植物学];
学科分类号
071001 ;
摘要
Three new ent-kaurane diterpenoids, named pterokaurane M-1-M-3 (1-3) and three new C-14 pterosin-sesquiterpenoids, named multifidoside A-C (4-6), along with 18 known compounds, were isolated from the whole plants of Pteris multifida. The structures of 1-6 were established using spectroscopic methods, including extensive 2D NMR and CD analyses. Compounds 4 and 5 showed cytotoxicity against the HepG2 tumor cell line with IC50 values of less than 10 mu M.
引用
收藏
页码:227 / 231
页数:5
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