Risk scores for metabolic dysfunction-associated fatty liver disease in pediatric obesity

被引:2
作者
Lischka, Julia [1 ]
Lieb, Katharina [1 ]
Schanzer, Andrea [1 ]
Hojreh, Azadeh [2 ]
Ba-Ssalamah, Ahmed [2 ]
de Gier, Charlotte
Walleczek, Nina-Katharina [1 ]
Zeyda, Maximilian [1 ,3 ]
Greber-Platzer, Susanne [1 ]
机构
[1] Med Univ Vienna, Comprehens Ctr Pediat, Dept Pediat & Adolescent Med, Clin Div Pediat Pulmonol, Waehringer Guertel 18-20, A-1090 Vienna, Austria
[2] Med Univ Vienna, Dept Biomed Imaging & Image guided Therapy, Waehringer Guertel 18-20, A-1090 Vienna, Austria
[3] Med Univ Vienna, Clin Div Pediat Pulmonol, Allergol & Endocrinol, Dept Pediat & Adolescent Med, Waehringer Guertel 18, Vienna A-201090, Austria
关键词
SIMPLE NONINVASIVE INDEX; SIGNIFICANT FIBROSIS; PREDICT; NAFLD; ULTRASOUND; DIAGNOSIS; CHILDREN;
D O I
10.1159/000526373
中图分类号
R5 [内科学];
学科分类号
1002 ; 100201 ;
摘要
Introduction: Early non-invasive detection of incipient liver damage is crucial to prevent long-term adverse health outcomes. A variety of scores to assess liver status have been proposed, mostly for adult populations. Validation of non-invasive hepatic scores to identify children at risk of metabolic dysfunction-associated fatty liver disease (MAFLD) is a gap in research, particularly in youth with severe obesity considering pubertal stage and sex. Methods: In a well-characterized pediatric population aged 9 to 19 years (n=115) 19 published liver scores were analyzed. AUROC for determination of MAFLD as assessed by magnetic resonance imaging was calculated. Results: The pediatric indices PNFI, B-AST and M-APRI and several scores developed in adults significantly differed in children with MAFLD compared to children without, while some established indices did not. Only NAFLD-LFS and the model by Cao et al. showed acceptable predictive accuracy (AUROC > 0.8) independently of pubertal stage and sex. When stratifying for pubertal stage and sex, the GSG-Index was superior in pubertal girls, and NAFLD-LFS performed best in pubertal boys. Conclusion: NAFLD-LFS and the model by Cao et al. were well suited to predict MAFLD in youth with severe obesity. In pubertal children, GSG-Index and NAFLD-LFS performed best in girls and boys, respectively.
引用
收藏
页码:247 / 254
页数:8
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