Neutrophil gelatinase-associated lipocalin (NGAL) as a Biomarker for Early Acute Kidney Injury

被引：51
作者：
Shemin, Douglas [1 ]
Dworkin, Lance D. [1 ]
机构：
[1] Brown Univ, Rhode Isl Hosp, Alpert Med Sch, Div Kidney Dis & Hypertens, Providence, RI 02903 USA
来源：
CRITICAL CARE CLINICS | 2011年 / 27卷 / 02期
关键词：
NGAL; Acule kidney injury; Acute tubular necrosis; ACUTE-RENAL-FAILURE; DELAYED GRAFT FUNCTION; CARDIAC-SURGERY; SERUM BIOMARKERS; EARLY MARKER; URINE NGAL; TRANSPLANTATION; INCREASES; RECOVERY; DIALYSIS;
D O I：
10.1016/j.ccc.2010.12.003
中图分类号：
R4 [临床医学];
学科分类号：
1002 ; 100602 ;
摘要：
Based on information to date, although limitations in the accuracy of NGAL in predicting AKI persist, the preponderance of published studies demonstrate that NGAL, when measured in the plasma and in the urine, is a reliable biomarker for the subsequent development of clinically apparent AKI. If very early detection of AKI, via the measurement of plasma or urinary NGAL, can be followed by effective treatment to abort the development or limit the severity of AKI, and therefore decrease the rate of RRT, length of hospitalization stay, and/or mortality risk, NGAL measurement will become a critically important diagnostic tool in critical care medicine, pediatrics, and surgery.
引用
收藏
页码：379 / +
页数：12
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