Distinct prognostic values of ALDH1 isoenzymes in breast cancer

被引：39

作者：

Wu, Shaokun ^{[1
]}

Xue, Weiping ^{[1
]}

Huang, Xiaobo ^{[2
]}

Yu, Xiaoli ^{[1
]}

Luo, Ming ^{[1
]}

Huang, Ying ^{[2
]}

Liu, Yimin ^{[1
]}

Bi, Zhuofei ^{[1
]}

Qiu, Xingsheng ^{[1
]}

Bai, Shoumin ^{[1
]}

机构：

[1] Sun Yat Sen Univ, Sun Yat Sen Mem Hosp, Dept Oncol, Guangzhou 510120, Peoples R China

[2] Sun Yat Sen Univ, Ctr Canc, Dept Radiotherapy, Guangzhou 510060, Guangdong, Peoples R China

来源：

TUMOR BIOLOGY | 2015年 / 36卷 / 04期

关键词：

Breast cancer; Cancer stem cell; ALDH1; Prognosis; KM plotter; ALDEHYDE DEHYDROGENASE; STEM-CELLS; POOR-PROGNOSIS; ANALYSIS TOOL; EXPRESSION; METASTASIS; SURVIVAL; DISEASE; MARKER; IDENTIFICATION;

D O I：

10.1007/s13277-014-2852-6

中图分类号：

R73 [肿瘤学];

学科分类号：

100214 ;

摘要：

Aldehyde dehydrogenase 1 (ALDH1), also known as aldehyde dehydrogenase 1 family, is composed of six enzymes that are expressed at high levels in stem cells and are involved in the regulation of stem cell function. Increased ALDH1 activity has been found in the stem cell populations of leukemia and some solid tumors including breast cancer (BC). However, which ALDH1's isoenzymes are contributing to ALDH1 activity has not been determined. In addition, the prognostic value of individual ALDH1 isoenzyme is not clear. In the current study, we investigated the prognostic value of ALDH1 isoenzymes in BC patients through "the Kaplan-Meier plotter" (KM plotter) database, in which updated gene expression data and survival information are from a total of 3455 BC patients. ALDH1A1 messenger RNA (mRNA) high expression was found to be correlated to worsen overall survival (OS) for all BC patients. ALDH1A2 and ALDH1L1 mRNA high expressions were found to be correlated to better OS for all BC patients. Both of ALDH1A3 and ALDH1B1 mRNA high expressions were not found to be correlated to OS for all BC patients. These results strongly support that ALDH1A1 was only a biomarker for predicting poor survival of BC patients among ALDH1 isoenzymes. ALDH1A1 might be a major contributor of ALDH1 activity in BC, since only ALDH1A1 mRNA high expression was found to be significantly correlated to worsen OS for all BC patients.

引用

页码：2421 / 2426

页数：6

共 44 条

[1] High Aldehyde Dehydrogenase Activity: A Novel Functional Marker of Murine Prostate Stem/Progenitor Cells [J].

Burger, Patricia E. ;

Gupta, Rashmi ;

Xiong, Xiaozhong ;

Ontiveros, Christopher S. ;

Salm, Sarah N. ;

Moscatelli, David ;

Wilson, E. Lynette .

STEM CELLS, 2009, 27 (09) :2220-2228

[2] ALDH1-Positive Cancer Stem Cells Predict Engraftment of Primary Breast Tumors and Are Governed by a Common Stem Cell Program [J].

Charafe-Jauffret, Emmanuelle ;

Ginestier, Christophe ;

Bertucci, Francois ;

Cabaud, Olivier ;

Wicinski, Julien ;

Finetti, Pascal ;

Josselin, Emmanuelle ;

Adelaide, Jose ;

Tien-Tuan Nguyen ;

Monville, Florence ;

Jacquemier, Jocelyne ;

Thomassin-Piana, Jeanne ;

Pinna, Guillaume ;

Jalaguier, Aurelie ;

Lambaudie, Eric ;

Houvenaeghel, Gilles ;

Xerri, Luc ;

Harel-Bellan, Annick ;

Chaffanet, Max ;

Viens, Patrice ;

Birnbaum, Daniel .

CANCER RESEARCH, 2013, 73 (24) :7290-7300

[3] Aldehyde Dehydrogenase 1-Positive Cancer Stem Cells Mediate Metastasis and Poor Clinical Outcome in Inflammatory Breast Cancer [J].

Charafe-Jauffret, Emmanuelle ;

Ginestier, Christophe ;

Iovino, Flora ;

Tarpin, Carole ;

Diebel, Mark ;

Esterni, Benjamin ;

Houvenaeghel, Gilles ;

Extra, Jean-Marc ;

Bertucci, Francois ;

Jacquemier, Jocelyne ;

Xerri, Luc ;

Dontu, Gabriela ;

Stassi, Giorgio ;

Xiao, Yi ;

Barsky, Sanford H. ;

Birnbaum, Daniel ;

Viens, Patrice ;

Wicha, Max S. .

CLINICAL CANCER RESEARCH, 2010, 16 (01) :45-55

[4] Inhibition of aldehyde dehydrogenase and retinoid signaling induces the expansion of human hematopoietic stem cells [J].

Chute, John P. ;

Muramoto, Garrett G. ;

Whitesides, John ;

Colvin, Michael ;

Safi, Rachid ;

Chao, Nelson J. ;

McDonnell, Donald P. .

PROCEEDINGS OF THE NATIONAL ACADEMY OF SCIENCES OF THE UNITED STATES OF AMERICA, 2006, 103 (31) :11707-11712

[5] Self-renewal and solid-tumor stem cells [J].

Clarke, MF .

BIOLOGY OF BLOOD AND MARROW TRANSPLANTATION, 2005, 11 (02) :14-16

[6] The cancer stem cell: premises, promises and challenges [J].

Clevers, Hans .

NATURE MEDICINE, 2011, 17 (03) :313-319

[7] The metastatic microenvironment of breast cancer: Clinical implications [J].

Coleman, R. E. ;

Gregory, W. ;

Marshall, H. ;

Wilson, C. ;

Holen, I. .

BREAST, 2013, 22 :S50-S56

[8] ALDH1 as a Functional Marker of Cancer Stem and Progenitor Cells [J].

Douville, Julie ;

Beaulieu, Raymond ;

Balicki, Danuta .

STEM CELLS AND DEVELOPMENT, 2009, 18 (01) :17-25

[9]

Ehlers CL, 2007, ALCOHOL RES HEALTH, V30, P14

[10] Identification of Cancer Stem Cells in Human Gastrointestinal Carcinoid and Neuroendocrine Tumors [J].

Gaur, Puja ;

Sceusi, Eric L. ;

Samuel, Shaija ;

Xia, Ling ;

Fan, Fan ;

Zhou, Yunfei ;

Lu, Jia ;

Tozzi, Federico ;

Lopez-Berestein, Gabriel ;

Vivas-Mejia, Pablo ;

Rashid, Asif ;

Fleming, Jason B. ;

Abdalla, Eddie K. ;

Curley, Steven A. ;

Vauthey, Jean-Nicolas ;

Sood, Anil K. ;

Yao, James C. ;

Ellis, Lee M. .

GASTROENTEROLOGY, 2011, 141 (05) :1728-1737

← 1 2 3 4 5 →