Acute Promyelocytic Leukemia: New treatment strategies with ATRA and ATO - AML-BFM-Recommendations

被引：8
作者：
Creutzig, Ursula [1 ]
Dworzak, Michael [2 ,3 ]
von Neuhoff, Nils [4 ]
Rasche, Mareike [4 ]
Reinhardt, Dirk [4 ]
机构：
[1] Hannover Med Sch Hannover, Pediat Hematol Oncol, Hannover, Germany
[2] St Anna Childrens Hosp, Vienna, Austria
[3] Med Univ Vienna, Childrens Canc Res Inst, Vienna, Austria
[4] Univ Hosp Essen, Dept Pediat Hematol Oncol, Pediat 3, Essen, Germany
来源：
KLINISCHE PADIATRIE | 2018年 / 230卷 / 06期
关键词：
acute promyelocytic leukemia; children; ATRA; Arsenic; TRANS-RETINOIC ACID; ACUTE MYELOGENOUS LEUKEMIA; AGENT ARSENIC TRIOXIDE; RISK GROUPS; FOLLOW-UP; CHILDHOOD; CHILDREN; THERAPY; TRIAL; CHEMOTHERAPY;
D O I：
10.1055/a-0750-5963
中图分类号：
R72 [儿科学];
学科分类号：
100202 ;
摘要：
The treatment of acute promyelocytic leukemia (APL) has changed significantly in recent years. Today, APL patients with standard risk (also known as low risk) can be treated chemotherapyfree only with all-trans-retinoic acid (ATRA) and arsenic trioxide (ATO). For high-risk patients, induction chemotherapy should be added. The curative results are good and comparable to those achieved in the past with chemotherapy plus ATRA. However, toxicities, especially infectious complications, are reduced. The main risk remains early lethal bleeding. Timely diagnosis and early ATRA treatment can reduce this risk. This review presents and discusses current treatment strategies and recommendations for APL in children.
引用
收藏
页码：299 / 304
页数：6
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