The role of the response to DNA damage in granulomatous diseases

被引：0
|
作者：
Fabry, Lea A. R. [1 ,2 ]
Triantafyllopoulou, Antigoni [1 ,2 ]
机构：
[1] Charite Univ Med Berlin, Med Klin mS Rheumatol & Klin Immunol, Charitepl 1, D-10117 Berlin, Germany
[2] Deutsch Rheuma Forschungszentrum, Inst Leibniz Gemeinschaft, Berlin, Germany
来源：
ZEITSCHRIFT FUR RHEUMATOLOGIE | 2022年 / 81卷 / 10期
关键词：
Granulomas; Multinucleated macrophages; DNA damage response; Genotoxic stress; Sarcoidosis; TUMOR-SUPPRESSOR; ATM ACTIVATION; IN-VIVO; STRESS; PATHWAY; REPAIR; TNF; MRE11-RAD50-NBS1; RECRUITMENT; ATRIP;
D O I：
10.1007/s00393-022-01260-y
中图分类号：
R5 [内科学];
学科分类号：
1002 ; 100201 ;
摘要：
Granulomas are organized aggregates of immune cells, which are formed in response to a persistent stimulus and are found in various rheumatic diseases, including sarcoidosis, rheumatoid arthritis and granulomatosis with polyangiitis. The core of granulomas contains a multitude of different macrophage subtypes, including multinucleated macrophages and foam cells. The mechanisms which induce the formation of granulomas are not well understood; however, recent data show that the DNA damage response regulates granuloma macrophage differentiation.
引用
收藏
页码：881 / 887
页数：7
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