Microfluidics and chromatography with an atomic force microscope

被引：13

作者：

Anderson, MS ^{[1
]}

机构：

[1] CALTECH, Jet Prop Lab, Pasadena, CA 91109 USA

来源：

ANALYTICAL CHEMISTRY | 2005年 / 77卷 / 09期

关键词：

D O I：

10.1021/ac048294k

中图分类号：

O65 [分析化学];

学科分类号：

070302 ; 081704 ;

摘要：

A combined atomic force microscope (AFM) and Raman spectrometer is presented as a microfluidic device for pumping, sampling, and trace chemical analysis. The AFM tip-cantilever provides a mechanism for sheardriven pumping of fluids in microchannels. Shear-driven pumping allows rapid flow rates and avoids the limitations of conventional pumping. The AFM's ability to translate sub-femtoliter volumes of fluid also proves a mechanism for fluidic switching and sample injection. In addition, the AFM is used to image liquid surfaces in microchannels and remove samples for very sensitive spectral analysis. Surface-enhanced Raman spectroscopy localized near the AFM tip provides chemical information of the sampled fluids. The results demonstrate the feasibility of integrating the AFM with microfluidic circuits and shear-driven chromatography and the potential for nanometer-scale chromatography.

引用

收藏

页码：2907 / 2911

页数：5

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