Rubiyunnanins C-H, cytotoxic cyclic hexapeptides from Rubia yunnanensis inhibiting nitric oxide production and NF-κB activation

被引：97

作者：

Fan, Jun-Ting ^{[1
,2
]}

Su, Jia ^{[1
,2
]}

Peng, Yan-Min ^{[2
,3
]}

Li, Yan ^{[1
]}

Li, Jia ^{[3
]}

Zhou, Yu-Bo ^{[3
]}

Zeng, Guang-Zhi ^{[1
]}

Yan, He ^{[1
,2
]}

Tan, Ning-Hua ^{[1
]}

机构：

[1] Chinese Acad Sci, State Key Lab Phytochem & Plant Resources W China, Kunming Inst Bot, Kunming 650204, Peoples R China

[2] Chinese Acad Sci, Grad Sch, Beijing 100039, Peoples R China

[3] Chinese Acad Sci, Shanghai Inst Mat Med, Natl Ctr Drug Screen, Shanghai 201203, Peoples R China

来源：

BIOORGANIC & MEDICINAL CHEMISTRY | 2010年 / 18卷 / 23期

基金：

中国国家自然科学基金;

关键词：

Rubia yunnanensis; Rubiyunnanins C-H; Cyclopeptides; Cytotoxicity; Inhibition of NO production; NF-kappa B pathway inhibitors; ANTITUMOR BICYCLIC HEXAPEPTIDES; BOUVARDIA-TERNIFOLIA; PROTEIN-SYNTHESIS; RA-VII; CONSTITUENTS; CORDIFOLIA; TRITERPENOIDS; RADIX; XI;

D O I：

10.1016/j.bmc.2010.10.019

中图分类号：

Q5 [生物化学]; Q7 [分子生物学];

学科分类号：

071010 ; 081704 ;

摘要：

Six new (rubiyunnanins C-H, 1-6) and five known (7-11) cyclic hexapeptides were isolated from the roots of Rubia yunnanensis (Franch.) Diels. The structures and stereochemistry of 1-6 were established by extensive spectroscopic analyses and chemical methods. All compounds (1-11) not only exhibited cytotoxic activities against a panel of eleven cancer cell lines with IC50 values ranging from 0.001 to 56.24 mu M, but also exerted inhibitory activities against nitric oxide (NO) production in LPS and IFN-gamma-induced RAW 264.7 murine macrophages with IC50 values ranging from 0.05 to 12.68 mu M. Furthermore, this is the first time it is being reported that compounds 2 and 7-10 significantly inhibited TNF-alpha-induced NF-kappa B activation in HEK-293-NF-kappa B luciferase stable cells with IC50 values of 35.07, 0.03, 1.69, 12.64 and 1.18 mu M, respectively. (C) 2010 Elsevier Ltd. All rights reserved.

引用

页码：8226 / 8234

页数：9

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