Conformationally restricted chiral peptide nucleic acids derived from azetidines

被引：3

作者：

Kovács, L

Hornyák, M

Howarth, NM

机构：

[1] Univ Szeged, Dept Med Chem, Nucle Acids Lab, H-6720 Szeged, Hungary

[2] Heriot Watt Univ, Dept Chem, Edinburgh, Midlothian, Scotland

来源：

NUCLEOSIDES NUCLEOTIDES & NUCLEIC ACIDS | 2003年 / 22卷 / 5-8期

关键词：

peptide nucleic acid analogues; conformational restriction; azetidines;

D O I：

10.1081/NCN-120022966

中图分类号：

Q5 [生物化学]; Q7 [分子生物学];

学科分类号：

071010 ; 081704 ;

摘要：

The initial experiments towards the chemical synthesis of conformationally rigid peptide nucleic acid analogues with azetidine moieties have been described.

引用

页码：1363 / 1365

页数：3

共 5 条

[1] Pyrrolidine nucleic acids:: DNA/PNA oligomers with 2-hydroxy/aminomethyl-4-(thymin-1-yl)pyrrolidine-N-acetic acid [J].

Kumar, V ;

Pallan, PS ;

Meena ;

Ganesh, KN .

ORGANIC LETTERS, 2001, 3 (09) :1269-1272

[2] Structural and biological properties of peptide nucleic acid (PNA) [J].

Nielsen, PE .

PURE AND APPLIED CHEMISTRY, 1998, 70 (01) :105-110

[3] Peptide nucleic acid (PNA). A DNA mimic with a pseudopeptide backbone [J].

Nielsen, PE ;

Haaima, G .

CHEMICAL SOCIETY REVIEWS, 1997, 26 (02) :73-78

[4] Synthesis and properties of novel pyrrolidinyl PNA carrying β-amino acid spacers [J].

Vilaivan, T ;

Suparpprom, C ;

Harnyuttanakorn, P ;

Lowe, G .

TETRAHEDRON LETTERS, 2001, 42 (32) :5533-5536

[5] Synthesis of C-glycosyl lactones and protected C-glycosyl amino acids:: Use of radical cyclization [J].

Zhang, JH ;

Clive, DLJ .

JOURNAL OF ORGANIC CHEMISTRY, 1999, 64 (03) :770-779

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