Nerve growth factor in the psychiatric brain

被引：50

作者：

Ciafre, Stefania ^{[1
]}

Ferraguti, Giampiero ^{[2
]}

Tirassa, Paola ^{[3
]}

Iannitelli, Angela ^{[4
]}

Ralli, Massimo ^{[5
]}

Greco, Antonio ^{[5
]}

Chaldakov, George N. ^{[6
]}

Rosso, Pamela ^{[2
]}

Fico, Elena ^{[2
]}

Messina, Marisa Patrizia ^{[7
]}

Carito, Valentina ^{[2
]}

Tarani, Luigi ^{[8
]}

Ceccanti, Mauro ^{[9
]}

Fiore, Marco ^{[2
]}

机构：

[1] IBCN CNR, Inst Cell Biol & Neurobiol, Inst Translat Pharmacol, Rome, Italy

[2] Sapienza Univ Rome, Dept Expt Med, Rome, Italy

[3] IBBC CNR, Inst Biochem & Cell Biol, Rome, Italy

[4] Univ Aquila, Dept Biotechnol & Appl Clin Sci, Laquila, Italy

[5] Sapienza Univ Rome, Dept Sense Organs, Rome, Italy

[6] Med Univ, Dept Anat & Cell Biol, Varna, Bulgaria

[7] Sapienza Univ Rome, Dept Gynecol Obstet & Urol, Rome, Italy

[8] Sapienza Univ Rome, Med Fac, Dept Pediat, Rome, Italy

[9] ASL Roma 1, Ctr Riferimento Alcol Reg Lazio, Rome, Italy

来源：

RIVISTA DI PSICHIATRIA | 2020年 / 55卷 / 01期

关键词：

NGF; Alzheimer disease; depression; brain; parasite; alcohol; neurodegeneration; SCHISTOSOMA-MANSONI INFECTION; PASSIVE-AVOIDANCE RESPONSE; NEUROTROPHIC FACTOR LEVELS; ALCOHOL-USE DISORDER; FACTOR GENE-THERAPY; BASAL FOREBRAIN; TRANSGENIC MICE; MOUSE MODEL; TNF-ALPHA; ALZHEIMERS-DISEASE;

D O I：

10.1708/3301.32713

中图分类号：

R749 [精神病学];

学科分类号：

100205 ;

摘要：

The nerve growth factor (NGF) belongs to a family of proteins named neurotrophins, consisting of NGF, brain-derived neurotrophic factor (BDNF), neurotrophin-3 (NT-3), NT-4/5 and NT-6. NGF regulates a large number of physiological mechanisms that result in neurotrophic, metabotrophic and/or immunotrophic effects. Neurodegenerative diseases, including Alzheimer disease, psychiatric disorders (e.g. depression and schizophrenia) and brain parasitic infection have in common the effect of changing the brain levels of neurotrophins, in particular NGF. The contribution of both NGF and its receptor TrkA in such events and the recent promising results of NGF based therapies are here presented and discussed.

引用

页码：4 / 15

页数：12

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