Involvement of ionotropic glutamate receptors in low frequency. electroacupuncture analgesia in rats

被引：22
作者：
Choi, BT [1 ]
Lee, JH
Wan, Y
Han, JS
机构：
[1] Dong Eui Univ, Res Inst Oriental Med, Coll Oriental Med, Dept Anat, Pusan 614052, South Korea
[2] Peking Univ, Hlth Sci Ctr, Neurosci Res Inst, Beijing 100083, Peoples R China
来源：
NEUROSCIENCE LETTERS | 2005年 / 377卷 / 03期
关键词：
electroacupuncture; NMDA; AMPA; KA;
D O I：
10.1016/j.neulet.2004.11.095
中图分类号：
Q189 [神经科学];
学科分类号：
071006 ;
摘要：
The present study was conducted to determine whether blockage of both N-methyl-D-aspartate (NMDA) and alpha-amino-3-hydroxy-5-methylisoxazole-4-proprionic acid/kainate (AMPA/KA) receptors influences the induction of low frequency electroacupuncture (EA) analgesia. Although neither intrathecal injection of NMDA antagonist D-2-amino-5-phosphonopentanoic acid (D-AP-5) or AMPA/KA antagonist 1,2,3,4-tetrahydro-6-nitro-2,3-dioxo-benzo[f]quinoxaline-7-sulfonami-de (NBQX) disodium alone had an effect on analgesia, spinal application Of D-AP-5 and NBQX disodium significantly prevented analgesia induced by 2 Hz EA. The intrathecal injection of the excitatory amino acid NMDA produced analgesia for several minutes after intrathecal injection, as did EA stimulation. These results suggest that ionotropic glutamate receptors may be involved in the induction of 2 Hz EA analgesia. (c) 2004 Elsevier Ireland Ltd. All rights reserved.
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页码：185 / 188
页数：4
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