A new bioactive coumestan from the seeds of Psoralea corylifolia

被引：10

作者：

Chai, Ming-Yan ^{[1
]}

机构：

[1] Zibo Vocat Inst, Dept Pharm & Biotechnol, Zibo 255314, Peoples R China

来源：

JOURNAL OF ASIAN NATURAL PRODUCTS RESEARCH | 2020年 / 22卷 / 03期

关键词：

Leguminosae; Psoralea corylifolia; obesity; coumestan; DGAT; alpha-glucosidase; DIACYLGLYCEROL ACYLTRANSFERASE; IDENTIFICATION; CONSTITUENTS; METABOLITES; FRUITS;

D O I：

10.1080/10286020.2018.1563073

中图分类号：

Q94 [植物学];

学科分类号：

071001 ;

摘要：

A new coumestan named bavacoumestan D (1), together with five known compounds (2-6), was isolated from EtOAc-soluble extract of seeds of Psoralea corylifolia. Their structures were elucidated on the basis of spectroscopic and physico-chemical analyses. All compounds were evaluated for in vitro inhibitory activity against DGAT1, DGAT2 and alpha-glucosidase. Among them, compounds 1-2, 5-6 showed potential inhibitory activity on DGAT1 with IC50 values ranging from 52.3 +/- 1.3 to 81.0 +/- 1.0 mu M. Compounds 1-3, 6 displayed the significant inhibitory activity on alpha-glucosidase with IC50 values ranging from 31.2 to 89.1 mu M.

引用

页码：295 / 301

页数：7

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