共 33 条
Development of a time-gated system for Raman spectroscopy of biological samples
被引:47
作者:

Knorr, Florian
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机构:
Univ Calif Davis, Ctr Biophoton Sci & Technol, Sacramento, CA 95817 USA Univ Calif Davis, Ctr Biophoton Sci & Technol, Sacramento, CA 95817 USA

Smith, Zachary J.
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机构:
Univ Calif Davis, Ctr Biophoton Sci & Technol, Sacramento, CA 95817 USA Univ Calif Davis, Ctr Biophoton Sci & Technol, Sacramento, CA 95817 USA

Wachsmann-Hogiu, Sebastian
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机构:
Univ Calif Davis, Ctr Biophoton Sci & Technol, Sacramento, CA 95817 USA
Univ Calif Davis, Dept Pathol & Lab Med, Sacramento, CA 95817 USA Univ Calif Davis, Ctr Biophoton Sci & Technol, Sacramento, CA 95817 USA
机构:
[1] Univ Calif Davis, Ctr Biophoton Sci & Technol, Sacramento, CA 95817 USA
[2] Univ Calif Davis, Dept Pathol & Lab Med, Sacramento, CA 95817 USA
来源:
OPTICS EXPRESS
|
2010年
/
18卷
/
19期
基金:
美国国家科学基金会;
关键词:
FLUORESCENCE SUPPRESSION;
TISSUE;
IDENTIFICATION;
REJECTION;
DIAGNOSIS;
SPECTRA;
CELLS;
BONE;
WOOD;
D O I:
10.1364/OE.18.020049
中图分类号:
O43 [光学];
学科分类号:
070207 ;
0803 ;
摘要:
A time gating system has been constructed that is capable of recording high quality Raman spectra of highly fluorescing biological samples while operating below the photodamage threshold. Using a collinear gating geometry and careful attention to power conservation, we have achieved all-optical switching with a one picosecond gating time and 5% peak gating efficiency. The energy per pulse in this instrument is more than 3 orders of magnitude weaker than previous reports. Using this system we have performed proof-of-concept experiments on a sample composed of perylene dissolved in toluene, and the stem of a Jasminum multiflorum plant, the latter case being particularly important for the study of plants used in production of cellulosic biofuels. In both cases, a high SNR spectrum of the high-wavenumber region of the spectrum was recorded in the presence of an overwhelming fluorescence background. (C) 2010 Optical Society of America
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收藏
页码:20049 / 20058
页数:10
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