The effect of occupational exposure on pro/antioxidant balance in the blood of non-smoking and smoking smelters with diabetes

被引：7
作者：
Bizon, A. [1 ]
Antonowicz-Juchniewicz, J. [2 ]
Milnerowicz, M. [3 ]
Sliwinska-Mosson, M. [1 ]
Milnerowicz, H. [1 ]
机构：
[1] Wroclaw Med Univ, Dept Biomed & Environm Anal, Borowska 211, PL-50556 Wroclaw, Poland
[2] Wroclaw Med Uniwers, Dept & Clin Internal & Occupat Dis & Hypertens, Borowska 213, PL-50556 Wroclaw, Poland
[3] Wroclaw Med Univ, Fac Med, PL-50556 Wroclaw, Poland
来源：
ENVIRONMENTAL TOXICOLOGY AND PHARMACOLOGY | 2016年 / 44卷
关键词：
Occupational exposure; Smoking; Pro/antioxidant balance; Smelters; Diabetes; INORGANIC ARSENIC EXPOSURE; GAMMA-GLUTAMYL-TRANSFERASE; OXIDATIVE STRESS; INSULIN-RESISTANCE; RISK; METALLOTHIONEIN; MELLITUS; ASSOCIATION; GLUTATHIONE; TOXICITY;
D O I：
10.1016/j.etap.2016.04.015
中图分类号：
X [环境科学、安全科学];
学科分类号：
08 ; 0830 ;
摘要：
Arsenic, lead and cadmium, potent environmental toxicants have been reported to induce diabetes mellitus, but their potential biological mechanism(s) have not been much investigated. The present study was designed to correlate parameters of pro/antioxidant balance with occupational exposure on heavy metals and smoking in smelters with diabetes compared on control group. The results showed a significant increase in the concentration of arsenic, cadmium and lead in the blood and urine of smelters, while smoking caused a further increase in the concentration of these metals. Increasing gamma-glutamyltransferase activity and lead concentration due to occupational exposure in copper foundry, tobacco smoke and co-existing diabetes were observed. Also these factors have synergistic effects on metallothionein and glutathione concentrations as well as glutathione dependent enzymes activities. Our data suggests that sub-chronic arsenic, lead and cadmium exposure induces diabetic condition which may be mediated due to increased oxidative stress in blood. (C) 2016 Elsevier B.V. All rights reserved.
引用
收藏
页码：99 / 106
页数：8
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