Synthesis of Benzothiazoles via Photooxidative Decarboxylation of α-Keto Acids

被引：51

作者：

Monga, Aparna ^{[1
]}

Bagchi, Sourav ^{[1
]}

Soni, Raj Kumar ^{[1
]}

Sharma, Anuj ^{[1
]}

机构：

[1] Indian Inst Technol Roorkee, Dept Chem, Roorkee 247667, Uttar Pradesh, India

来源：

ADVANCED SYNTHESIS & CATALYSIS | 2020年 / 362卷 / 11期

关键词：

Benzothiazoles; Blue LED; Decarboxylation; EDA complex; alpha-Keto acids; Photooxidative cross-coupling; BIOLOGICAL EVALUATION; LIGHT-IRRADIATION; N-HETEROARENES; ACYLATION; DERIVATIVES; COMPLEXES; POTENT; INHIBITORS; AMIDATION; AMINES;

D O I：

10.1002/adsc.201901617

中图分类号：

O69 [应用化学];

学科分类号：

081704 ;

摘要：

Herein, synthesis of benzothiazoles via decarboxylative cross-coupling between alpha-keto acids and 2-aminothiophenols under blue LED irradiation without using any photocatalyst or metal at room temperature is described. The formation of benzothiazole is driven by the EDA (electron donor-acceptor) complex formed between alpha-keto acid and 2-aminothiophenol. This methodology gives easy access to 2-substituted and -unsubstituted benzothiazoles in moderate to good yields. alpha-Keto acids and 2-aminothiophenols bearing different functional groups were easily transformed under the given conditions.

引用

页码：2232 / 2237

页数：6

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