Single center study on ethnic and clinical features of Behcet's disease in Moscow, Russia

被引:14
作者
Lennikov, Anton [1 ]
Alekberova, Zemfira [2 ]
Goloeva, Regina [2 ]
Kitaichi, Nobuyoshi [3 ,4 ]
Denisov, Lev [2 ]
Namba, Kenichi [1 ]
Takeno, Mitsuhiro [5 ]
Ishigatsubo, Yoshiaki [5 ]
Mizuki, Nobuhisa [6 ]
Nasonov, Eugeny [2 ]
Ishida, Susumu [1 ,4 ]
Ohno, Shigeaki [1 ]
机构
[1] Hokkaido Univ, Grad Sch Med, Dept Ophthalmol, Sapporo, Hokkaido 0608638, Japan
[2] Russian Acad Med Sci, Res Inst Rheumatol, Moscow, Russia
[3] Hlth Sci Univ Hokkaido, Dept Ophthalmol, Sapporo, Hokkaido, Japan
[4] Hokkaido Univ, Grad Sch Med, Dept Ocular Inflammat & Immunol, Kita Ku, Sapporo, Hokkaido 0608638, Japan
[5] Yokohama City Univ, Grad Sch Med, Dept Internal Med & Clin Immunol, Yokohama, Kanagawa 232, Japan
[6] Yokohama City Univ, Grad Sch Med, Dept Ophthalmol & Visual Sci, Yokohama, Kanagawa 232, Japan
基金
日本学术振兴会;
关键词
Behcet's disease; Caucasus; Central Asia; Clinical symptoms; Russia; Silk Road disease; GENOME-WIDE ASSOCIATION; IL23R-IL12RB2; IL10;
D O I
10.1007/s10067-013-2442-9
中图分类号
R5 [内科学];
学科分类号
1002 ; 100201 ;
摘要
For the purpose of investigating Behcet's disease (BD) in Russia, 250 consecutive patients (177 men and 73 women) diagnosed with BD between 1990 and 2010 at the Research Institute of Rheumatology, Russian Academy of Medical Sciences in Moscow were enrolled in this study. The ethnic backgrounds of the patients were reported as follows: 23.2 % (58 cases) from Russia, 12.8 % (32 cases) from Azerbaijan, 14.4 % (36 cases) from Armenia, 8.8 % (22 cases) from Chechnya, and 21.6 % (55 cases) from Dagestan. The remaining 19.2 % (48 cases) were from other regions or of unknown origin. More than half (57.6 %) of the Behcet's disease patients originated from Central Asia, specifically Azerbaijan, Armenia, Chechnya, and Dagestan. The mean age at disease onset was 31.5 +/- 9.38 (13-60) years old, and the most typical initial manifestations were oral aphthous ulcers. Patients aged 20-39 years old were more commonly affected and displayed a wide clinical spectrum of the disease, with varieties of severe internal organ involvement. The manifestations observed throughout the course of the disease included oral aphthous ulcers (100 %), various cutaneous lesions (88.8 %), genital ulcers (81.2 %), and ocular lesions (54.0 %). Besides these, many organs/systems were implicated in patient cases, namely joint (53.2 %), vascular (25.2 %), neurological (8.0 %), gastrointestinal (25.2 %), and cardiac (5.6 %) systems. Involvements of ocular (p < 0.01) and skin (p < 0.01) lesions were more frequent in men than in women. HLA-B51 and HLA-A26 typing was performed in 127 patients and 508 healthy controls. HLA-B51 was found in 63.0 % of BD patients compared to 20.7 % of the healthy control subjects (p < 0.001), and HLA-A26 was present in 11.3 % of BD patients and 18.9 % of the control group. This study shows the presence of BD in Russia, and it is suggested that its prevalence in Central Asian people is much higher than that in White Russian.
引用
收藏
页码:321 / 327
页数:7
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