The role of enhancer RNAs in epigenetic regulation of gene expression

被引：10

作者：

Rahnamoun, Homa ^{[1
]}

Orozco, Paola ^{[1
]}

Lauberth, Shannon M. ^{[1
]}

机构：

[1] Univ Calif San Diego, Sect Mol Biol, La Jolla, CA 92093 USA

来源：

TRANSCRIPTION-AUSTIN | 2020年 / 11卷 / 01期

基金：

美国国家科学基金会;

关键词：

Enhancer; eRNA; chromatin; histone modification; bromodomain; BRD4; transcription; gene regulation; NF-KAPPA-B; TRANSCRIPTION FACTORS; SELECTIVE-INHIBITION; PHASE-SEPARATION; P-TEFB; BINDING; CHROMATIN; BRD4; ACETYLATION; RECOGNITION;

D O I：

10.1080/21541264.2019.1698934

中图分类号：

Q5 [生物化学]; Q7 [分子生物学];

学科分类号：

071010 ; 081704 ;

摘要：

Since the discovery that enhancers can support transcription, the roles of enhancer RNAs have remained largely elusive. We identified that enhancer RNAs interact with and augment bromodomain engagement with acetylated chromatin. Here, we discuss our recent findings and the potential mechanisms underlying the regulation and functions of enhancer RNA-bromodomain associations.

引用

页码：19 / 25

页数：7

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