Detection of neurotransmitters by a light scattering technique based on seed-mediated growth of gold nanoparticles

被引：16
作者：
Shang, Li [1 ]
Dong, Shaojun [1 ]
机构：
[1] Chinese Acad Sci, Changchun Inst Appl Chem, Grad Sch, State Key Lab Electroanalyt Chem, Changchun 130022, Peoples R China
来源：
NANOTECHNOLOGY | 2008年 / 19卷 / 09期
关键词：
D O I：
10.1088/0957-4484/19/9/095502
中图分类号：
TB3 [工程材料学];
学科分类号：
0805 ; 080502 ;
摘要：
A simple light scattering detection method for neurotransmitters has been developed, based on the growth of gold nanoparticles. Neurotransmitters (dopamine, L-dopa, noradrenaline and adrenaline) can effectively function as active reducing agents for generating gold nanoparticles, which result in enhanced light scattering signals. The strong light scattering of gold nanoparticles then allows the quantitative detection of the neurotransmitters simply by using a common spectrofluorometer. In particular, Au-nanoparticle seeds were added to facilitate the growth of nanoparticles, which was found to enhance the sensing performance greatly. Using this light scattering technique based on the seed-mediated growth of gold nanoparticles, detection limits of 4.4 x 10(-7) M, 3.5 x 10(-7) M, 4.1 x 10(-7) M, and 7.7 x 10(-7) M were achieved for dopamine, L-dopa, noradrenaline and adrenaline, respectively.
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页数：6
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