Translocator protein (18 kDa) (TSPO) as a therapeutic target for neurological and psychiatric disorders

被引：755

作者：

Rupprecht, Rainer ^{[1
,2
]}

Papadopoulos, Vassilios ^{[3
,4
,5
,6
,7
]}

Rammes, Gerhard ^{[2
,8
]}

Baghai, Thomas C. ^{[1
]}

Fan, Jinjiang ^{[3
,4
,5
,6
,7
]}

Akula, Nagaraju ^{[9
]}

Groyer, Ghislaine ^{[10
,11
]}

Adams, David ^{[12
]}

Schumacher, Michael ^{[10
,11
]}

机构：

[1] Univ Munich, Dept Psychiat & Psychotherapy, D-80336 Munich, Germany

[2] Max Planck Inst Psychiat, D-80804 Munich, Germany

[3] McGill Univ, Res Inst, Ctr Hlth, Montreal, PQ H3G 1A4, Canada

[4] McGill Univ, Dept Med, Montreal, PQ H3G 1A4, Canada

[5] McGill Univ, Dept Pharmacol, Montreal, PQ H3G 1A4, Canada

[6] McGill Univ, Dept Therapeut, Montreal, PQ H3G 1A4, Canada

[7] McGill Univ, Dept Biochem, Montreal, PQ H3G 1A4, Canada

[8] Tech Univ Munich, Dept Anesthesiol, D-81675 Munich, Germany

[9] Georgetown Univ, Med Ctr, Dept Biochem & Mol & Cellular Biol, Washington, DC USA

[10] INSERM, UMR 788, F-94276 Le Kremlin Bicetre, France

[11] Univ Paris 11, F-94276 Le Kremlin Bicetre, France

[12] Hop Bicetre, AP HP, Dept Neurol, F-94276 Le Kremlin Bicetre, France

来源：

NATURE REVIEWS DRUG DISCOVERY | 2010年 / 9卷 / 12期

基金：

加拿大健康研究院;

关键词：

PERIPHERAL BENZODIAZEPINE-RECEPTOR; DIAZEPAM-BINDING INHIBITOR; CENTRAL-NERVOUS-SYSTEM; EXTRASYNAPTIC GABA(A) RECEPTORS; ADULT SEPARATION ANXIETY; DEPENDENT ANION CHANNEL; MICROGLIAL ACTIVATION; CHOLESTEROL TRANSPORT; IN-VITRO; NEUROACTIVE STEROIDS;

D O I：

10.1038/nrd3295

中图分类号：

Q81 [生物工程学（生物技术）]; Q93 [微生物学];

学科分类号：

071005 ; 0836 ; 090102 ; 100705 ;

摘要：

The translocator protein (18 kDa) (TSPO) is localized primarily in the outer mitochondrial membrane of steroid-synthesizing cells, including those in the central and peripheral nervous system. One of its main functions is the transport of the substrate cholesterol into mitochondria, a prerequisite for steroid synthesis. TSPO expression may constitute a biomarker of brain inflammation and reactive gliosis that could be monitored by using TSPO ligands as neuroimaging agents. Moreover, initial clinical trials have indicated that TSPO ligands might be valuable in the treatment of neurological and psychiatric disorders. This Review focuses on the biology and pathophysiology of TSPO and the potential of currently available TSPO ligands for the diagnosis and treatment of neurological and psychiatric disorders.

引用

页码：971 / 988

页数：18

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