Antibacterial activity of α-mangostin against vancomycin resistant Enterococci (VRE) and synergism with antibiotics

被引：167

作者：

Sakagami, Y ^{[1
]}

Iinuma, M

Piyasena, KGN

Dharmaratne, HRW

机构：

[1] Osaka Prefectural Inst Publ Hlth, Osaka 537, Japan

[2] Gifu Pharmaceut Univ, Gifu, Japan

[3] Inst Fundamental Studies, Nat Prod Programme, Kandy, Sri Lanka

来源：

PHYTOMEDICINE | 2005年 / 12卷 / 03期

关键词：

mangostin; Garcinia mangostan; antibacterial activity; vancomycin resistant Enterococci; synergy effect with antibiotics;

D O I：

10.1016/j.phymed.2003.09.012

中图分类号：

Q94 [植物学];

学科分类号：

071001 ;

摘要：

alpha-Mangostin, isolated from the stem bark of Garcinia mangostana L., was found to be active against vancomycin resistant Enterococci (VRE) and methicillin resistant Staphylococcus aureus (MRSA), with MIC values of 6.25 and 6.25 to 12.5 mu g/ml, respectively. Our studies showed synergism between alpha-mangostin and gentamicin (GM) against VRE, and alpha-mangostin and vancomycin hydrochloride (VCM) against MRSA. Further studies showed partial synergism between alpha-mangostin and commercially available antibiotics such as ampicillin and minocycline. These findings suggested that alpha-mangostin alone or in combination with GM against VRE and in combination with VCM against MRSA might be useful in controlling VRE and MRSA infections. (c) 2004 Published by Elsevier GmbH.

引用

页码：203 / 208

页数：6

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