Toe dystonia in Parkinson's disease: Impact of subthalamic nucleus deep brain stimulation

被引：1

作者：

Laurencin, Chloe ^{[1
,2
]}

Montaut, Solveig ^{[1
,3
]}

Vial, Christophe ^{[4
]}

Bernard, Lorraine ^{[5
]}

Bin, Sylvie ^{[5
]}

Rascle, Lucie ^{[2
]}

Polo, Gustavo ^{[6
]}

Mertens, Patrick ^{[6
]}

Danaila, Teodor ^{[1
,2
]}

Thobois, Stephane ^{[1
,2
,7
]}

机构：

[1] CNRS, UMR 5229, Inst Sci Cognit Marc Jeannerod, Bron, France

[2] Hosp Civils Lyon, Hop Neurol Pierre, Ctr Expert Parkinson, Serv Neurol C, Lyon, France

[3] Hop Univ Strasbourg, Hop Hautepierre, Serv Neurol, Strasbourg, France

[4] Hosp Civils Lyon, Hop Neurol Pierre Wertheimer, Serv Electroneuromyog, Lyon, France

[5] Hosp Civils Lyon, Pole IMER, Unite Rech Clin, Lyon, France

[6] Hosp Civils Lyon, Hop Neurol Pierre Wertheimer, Serv Neurochirurg A, Lyon, France

[7] Univ Lyon, Univ Lyon 1, Fac Med Lyon Sud Charles Merieux, Lyon, France

来源：

JOURNAL OF THE NEUROLOGICAL SCIENCES | 2018年 / 392卷

关键词：

Parkinson's disease; Toe dystonia; Deep brain stimulation; Levodopa induced dyskinesia; Subthalamic nucleus; MOTOR COMPLICATIONS; SEX-DIFFERENCES; YOUNG-ONSET; DYSKINESIAS; FEATURES; TOXIN; AGE;

D O I：

10.1016/j.jns.2018.07.004

中图分类号：

R74 [神经病学与精神病学];

学科分类号：

摘要：

Background: Off state toe dystonia (TD) is a symptom frequently encountered in Parkinson's disease (PD), but little is known about its evolution after subthalamic nucleus deep brain stimulation (STN-DBS). Objective: To analyze the prevalence and the evolution of TD in PD patients candidate to STN-DBS. Methods: Individual data of consecutive 130 PD patients who underwent STN-DBS between 2010 and 2015 were collected. Results: Data were successfully collected in 95 patients. TD affect 45.3% of the patients in our cohort. TD was present in 32.7% of patients before surgery and was alleviated by STN-DBS in 48% of the cases. Motor improvement provided by STN-DBS, levodopa-equivalent treatment diminution after surgery, disease duration or age at the time of surgery were not predictive of TD evolution. A younger age at PD diagnosis was significantly associated with TD resolution. Conclusion: STN-DBS is partially efficient for TD but its evolution seems independent of significant predictive factors.

引用

页码：65 / 68

页数：4

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