Clinical outcome from hematopoietic cell transplant patients with bloodstream infection caused by carbapenem-resistant P. aeruginosa and the impact of antimicrobial combination in vitro

被引：4
作者：
Ramos, Jessica Fernandes [1 ,2 ]
Leite, Gleice [3 ]
Martins, Roberta Cristina Ruedas [3 ]
Rizek, Camila [3 ]
Al Sanabani, Sabri Saeed [4 ]
Rossi, Flavia [5 ]
Guimaraes, Thais [1 ,3 ]
Levin, Anna Sara [1 ,3 ]
Rocha, Vanderson [2 ,6 ]
Costa, Silvia Figueiredo [1 ,3 ]
机构：
[1] Univ Sao Paulo, Dept Infect Dis, Fac Med, Sao Paulo, Brazil
[2] Univ Sao Paulo, Dept Haematol Hemotherapy & Cellular Therapy, Fac Med, Sao Paulo, Brazil
[3] Univ Sao Paulo, Lab Med Invest LIM 49, Inst Trop Med, Sao Paulo, Brazil
[4] Univ Sao Paulo, Lab Med Invest LIM 52, Inst Trop Med, Sao Paulo, Brazil
[5] Univ Sao Paulo, Lab Clin Microbiol, Fac Med, Hosp Clin, Sao Paulo, Brazil
[6] Univ Oxford, Dept Haematol, NHS BT, Oxford, England
来源：
EUROPEAN JOURNAL OF CLINICAL MICROBIOLOGY & INFECTIOUS DISEASES | 2022年 / 41卷 / 02期
关键词：
Carbapenem-resistant Pseudomonas aeruginosa; Multidrug resistance; Virulence; Synergism; Stem cell transplant; Bloodstream infection; PSEUDOMONAS-AERUGINOSA; MORTALITY; VIRULENCE; THERAPY; METAANALYSIS; BACTEREMIA; MECHANISMS; SYNERGY; AGENTS; GENES;
D O I：
10.1007/s10096-021-04361-9
中图分类号：
R51 [传染病];
学科分类号：
100401 ;
摘要：
Bloodstream infection (BSI) caused by carbapenem-resistant P. aeruginosa (CRPA) has high mortality in hematopoietic stem cell transplant (HSCT) recipients. We performed MIC, checkerboard, time-kill assay, PFGE, PCR, and whole genome sequence and described the clinical outcome through Epi Info comparing the antimicrobial combination in vitro. Mortality was higher in BSI caused by CRPA carrying the lasB virulence gene. The isolates were 97% resistant to meropenem displaying synergistic effect to 57% in combination with colistin. Seventy-three percent of the isolates harbored bla(SPM-1) and Tn4371 and belonged to ST277. The synergistic effect in vitro with meropenem with colistin appeared to be a better therapeutic option.
引用
收藏
页码：313 / 317
页数：5
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