Maternal inhaled fluticasone propionate intake during pregnancy is detected in neonatal cord blood

被引：2

作者：

Battista, Marie-Claude ^{[1
]}

Boutin, Michel ^{[2
]}

Venne, Philippe ^{[2
]}

Blais, Lucie ^{[3
,4
,5
]}

Berard, Anick ^{[4
,6
]}

Lacroix, Marilyn ^{[1
]}

Patenaude, Julie ^{[1
]}

Guillemette, Laetitia ^{[1
]}

Cossette, Benoit ^{[3
,4
,7
]}

Hivert, Marie-France ^{[1
,3
,8
,9
]}

Auray-Blais, Christiane ^{[2
,3
]}

机构：

[1] Univ Sherbrooke, Div Endocrinol, Dept Med, Fac Med & Hlth Sci, Sherbrooke, PQ J1K 2R1, Canada

[2] Univ Sherbrooke, Dept Pediat, Fac Med & Hlth Sci, Div Med Genet, Sherbrooke, PQ J1K 2R1, Canada

[3] CHU Sherbrooke, Ctr Rech, Sherbrooke, PQ J1H 5N4, Canada

[4] Univ Montreal, Fac Pharm, Quebec City, PQ, Canada

[5] Hop Sacre Coeur Montreal, Res Ctr, Quebec City, PQ, Canada

[6] CHU Ste Justine, Res Ctr, Montreal, PQ, Canada

[7] Univ Sherbrooke, Fac Med & Hlth Sci, Dept Pharm, Sherbrooke, PQ J1K 2R1, Canada

[8] Harvard Univ, Sch Med, Harvard Pilgrim Hlth Care Inst, Dept Populat Med, Boston, MA USA

[9] Massachusetts Gen Hosp, Boston, MA 02114 USA

来源：

BIOANALYSIS | 2016年 / 8卷 / 14期

关键词：

asthma; cord blood; fluticasone propionate; pregnancy; UPLC-MS/MS; BUDESONIDE FOLLOWING INHALATION; DRY-POWDER INHALERS; LC-MS/MS; PLASMA-CONCENTRATIONS; MULTIPLEX ANALYSIS; ASTHMA; INTRANASAL; SALMETEROL; SAFETY; CORTICOSTEROIDS;

D O I：

10.4155/bio-2016-0065

中图分类号：

Q5 [生物化学];

学科分类号：

071010 ; 081704 ;

摘要：

Background: Despite recommendations to use inhaled corticosteroids as treatment to control asthma during pregnancy, it is unknown whether inhaled fluticasone propionate (FP) reaches the fetus. Results & methodology: We collected maternal blood on the morning following delivery. FP was detected by ultra-performance LC-MS/MS (UPLC-MS/MS) in 9/17 asthmatic women using FP. Delay between last FP inhalation and maternal blood sampling ranged between 3 and 33 h and FP was detected in a range of 1.572-46.440 pg/ml. Among the nine offspring of these FP users, FP was detected in five cord blood samples. Delay between last predelivery FP inhalation and cord blood sampling ranged from 4 to 20 h and FP was detected in a range of 0.423-4.510 pg/ml. Conclusion: Our findings demonstrate placental passage of inhaled FP.

引用

页码：1441 / 1450

页数：10

共 37 条

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