Anti-platelet aggregation constituents from formosan Toddalia asiatica

被引：80

作者：

Tsai, IL

Wun, MF

Teng, CM

Ishikawa, T

Chen, IS ^{[1
]}

机构：

[1] Kaohsiung Med Coll, Grad Inst Pharmaceut Sci, Kaohsiung, Taiwan

[2] Natl Taiwan Univ, Coll Med, Pharmactol Inst, Taipei 10018, Taiwan

[3] Chiba Univ, Fac Pharmaceut Sci, Chiba 260, Japan

来源：

PHYTOCHEMISTRY | 1998年 / 48卷 / 08期

关键词：

Toddalia asiatica; Rutaceae; wood; toddanin; coumarin; (-)-isocoreximine; tetrahydroprotoberberine; cyclohexylamine; benzo[c]phenanthridine; alkaloids; lignan; anti-platelet aggregation;

D O I：

10.1016/S0031-9422(97)00678-X

中图分类号：

Q5 [生物化学]; Q7 [分子生物学];

学科分类号：

071010 ; 081704 ;

摘要：

Examination on the wood of Formosan Toddalia asiatica led to the isolation of 30 compounds, including coumarins, alkaloids, a benzoquinone and an amine. Among the isolates, (+/-)-toddanin and (-)-isocoreximine are new compounds, while cyclohexylamine was isolated for the first time from nature. The structures of the compounds were elucidated from spectroscopic data and chemical evidence. Bioassay-guided fractionation led to the isolation of seven compounds showing strong anti-platelet aggregation activity in vitro. (C) 1998 Elsevier Science Ltd. All rights reserved.

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页码：1377 / 1382

页数：6

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