MTHFR association with arteriosclerotic vascular disease?

被引：95
作者：
Fletcher, O [1 ]
Kessling, AM [1 ]
机构：
[1] Northwick Pk & St Marks NHS Trust, Imperial Coll Sch Med, Kennedy Galton Ctr, Harrow HA1 3UJ, Middx, England
来源：
HUMAN GENETICS | 1998年 / 103卷 / 01期
关键词：
D O I：
10.1007/s004390050776
中图分类号：
Q3 [遗传学];
学科分类号：
071007 ; 090102 ;
摘要：
Complex diseases are far more common than diseases that follow simple Mendelian patterns of inheritance. Difficulties are experienced in the designing of experiments to dissect out the contribution of a single allele to a complex phenotype. We review the literature regarding a point mutation in methylenetetrahydrofolate reductase, a candidate gene for susceptibility to vascular diseases.
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页码：11 / 21
页数：11
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