The changing spectrum of antibody-mediated encephalitis in China

被引：43
作者：
Ren, Haitao [1 ]
Fan, Siyuan [1 ]
Zhao, Yanhuan [1 ]
Guan, Hongzhi [1 ]
机构：
[1] Chinese Acad Med Sci & Peking Union Med Coll, Peking Union Med Coll Hosp, Dept Neurol, Beijing 100730, Peoples R China
来源：
JOURNAL OF NEUROIMMUNOLOGY | 2021年 / 361卷
关键词：
Autoimmune encephalitis; Antibody panel; Spectrum; Change; RECEPTOR ANTIBODIES; CASE SERIES;
D O I：
10.1016/j.jneuroim.2021.577753
中图分类号：
R392 [医学免疫学]; Q939.91 [免疫学];
学科分类号：
100102 ;
摘要：
In the past 5 years, the positivity rate of autoimmune encephalitis antibody panels has significantly decreased in patients with clinically suspected encephalitis in an encephalitis center in China. Furthermore, the spectrum of patients with autoantibodies related to autoimmune encephalitis has changed significantly, exhibiting a decreased percentage of patients with anti-N-methyl-D-aspartate receptor antibodies and an increased percentage of patients with infrequently observed autoantibodies. Meanwhile, a small but non-negligible proportion of patients with autoantibodies against cell surface and synaptic proteins exhibited positivity for more than one autoantibody.
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页数：4
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