On the stereoselective hydrogenation of chiral cyclobutyl dehydro-amino acid derivatives:: influence of the catalyst in the π-facial diastereoselection

被引：11
作者：
Aguado, GP
Alvarez-Larena, A
Illa, O
Moglioni, AG
Ortuño, RM [1 ]
机构：
[1] Univ Autonoma Barcelona, Dept Quim, E-08193 Barcelona, Spain
[2] Univ Autonoma Barcelona, Unitat Cristallog, E-08193 Barcelona, Spain
来源：
TETRAHEDRON-ASYMMETRY | 2001年 / 12卷 / 01期
关键词：
D O I：
10.1016/S0957-4166(01)00026-X
中图分类号：
O61 [无机化学];
学科分类号：
070301 ; 081704 ;
摘要：
Several optically active cyclobutyl dehydro-amino acid derivatives have been hydrogenated employing Wilkinson, (S,S)-chiraphos-Rh and Et-duphos-Rh (both enantiomers) as catalysts. The use of a chiral catalyst has been revealed to be crucial for the production of saturated amino acids with high stereoselectivity from substrates in which the chiral cyclobutyl unit is separated from the double bond by a methylene group. (C) 2001 Elsevier Science Ltd. All rights reserved.
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页码：25 / 28
页数：4
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