Estrogen receptor Alpha in human knee articular cartilage of healthy and osteoarthritic females

被引：15

作者：

Hughbanks, Marissa L. ^{[1
,2
]}

Rodriguez-Fontan, Francisco ^{[2
]}

Kleck, Christopher J. ^{[2
,3
]}

Burger-Van der Walt, Evalina ^{[2
,3
]}

机构：

[1] Univ Colorado, Sch Med, Anschutz Med Campus, Aurora, CO USA

[2] Univ Colorado, Dept Orthoped, Anschutz Med Campus, 13001 E 17th Pl, Aurora, CO 80045 USA

[3] Univ Colorado Hosp, Spine Ctr, Aurora, CO USA

来源：

JOURNAL OF ORTHOPAEDICS | 2021年 / 27卷

关键词：

Estrogen receptor; Osteoarthritis; Menopause; Estradiol; REPLACEMENT-THERAPY; RHEUMATOID-ARTHRITIS; POSTMENOPAUSAL WOMEN; GENE HAPLOTYPE; TESTOSTERONE; CHONDROCYTES; POLYMORPHISM; INHIBITION; PREVALENCE; CONVERSION;

D O I：

10.1016/j.jor.2021.08.005

中图分类号：

R826.8 [整形外科学]; R782.2 [口腔颌面部整形外科学]; R726.2 [小儿整形外科学]; R62 [整形外科学（修复外科学）];

学科分类号：

摘要：

Objective: Estrogen and osteoarthritis association has previously been proposed. This study evaluates the presence of estrogen receptors (ER)-alpha in articular cartilage, and its association. Methods: A prospective cohort study of women undergoing anterior cruciate ligament reconstruction (controls) or total knee arthroplasty (cases) was performed. Cartilage samples were processed and ER-alpha expression was quantified. Results: Twenty patients were included: 12 cases and 8 controls. ER-alpha expression was higher in the case subjects. Conclusion: Increased ER-alpha expression is associated with age, and degeneration. This suggests estrogen deficiency is a risk for osteoarthritis and is inversely related to proliferative looking chondrocytes.

引用

页码：1 / 8

页数：8

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