Development of bozepinib-loaded nanocapsules for nose-to-brain delivery: preclinical evaluation in glioblastoma

被引：7

作者：

Dias, Amanda de Fraga ^{[1
]}

Dallemole, Danieli Rosane ^{[2
]}

Bruinsmann, Franciele Aline ^{[2
]}

Lopes Silva, Luiz Fernando ^{[1
]}

Cruz-Lopez, Olga ^{[3
,4
]}

Conejo-Garcia, Ana ^{[3
,4
]}

Oliveira Battastini, Ana Maria ^{[1
]}

Maria Campos, Joaquin ^{[3
,4
]}

Guterres, Silvia Staniscuaski ^{[2
]}

Pohlmann, Adriana Raffin ^{[2
]}

Figueiro, Fabricio ^{[1
,5
]}

机构：

[1] Univ Fed Rio Grande do Sul, Inst Ciencias Basicas Saude, Programa Posgrad Ciencias Biol Bioquim, Porto Alegre, RS, Brazil

[2] Univ Fed Rio Grande do Sul, Fac Farm, Programa Posgrad Ciencias Farmaceut, Porto Alegre, RS, Brazil

[3] Fac Farm, Dept Quim Farmaceut & Organ, C Campus Cartuja S-N, Granada, Spain

[4] Inst Invest Biosanitaria Granada Ibs GRANADA, Granada, Spain

[5] Univ Fed Rio Grande do Sul, Inst Ciencias Basicas Saude, Dept Bioquim, Porto Alegre, RS, Brazil

来源：

NANOMEDICINE | 2021年 / 16卷 / 23期

关键词：

bozepinib; drug delivery; glioblastoma; intranasal; lipid-core nanocapsules; temozolomide; LIPID-CORE NANOCAPSULES; DRUG-DELIVERY; POLYMERIC NANOPARTICLES; INTRANASAL DELIVERY; EXPERIMENTAL-DESIGN; GROWTH-INHIBITION; IN-VITRO; CHITOSAN; COMBINATION; GLIOMA;

D O I：

10.2217/nnm-2021-0164

中图分类号：

Q81 [生物工程学（生物技术）]; Q93 [微生物学];

学科分类号：

071005 ; 0836 ; 090102 ; 100705 ;

摘要：

Aim: To develop and characterize bozepinib-loaded lipid-core nanocapsules (BZP-LNC+) as a potential treatment for glioblastoma (GBM). Methods: Characterization of nanocapsules was performed by diameter, polydispersity index, zeta potential, pH and encapsulation efficiency. GBM cell viability, cell cycle and Annexin/PI were evaluated after BZP-LNC+ treatment. Synergism between BZP-LNC+ and temozolomide (TMZ) was performed by CompuSyn software and confirmed in vitro and in vivo. Results: BZP-LNC+ showed adequate particle sizes, positive zeta potential, narrow size distribution and high encapsulation efficiency. BZP-LNC+ reduces GBM growth by inducing apoptosis. BZP-LNC+ and TMZ showed synergistic effect in vitro and reduced the in vivo glioma growth by approximately 81%. Conclusion: The present study provides proof-of-principle insights for the combination of these drugs for GBM treatment.

引用

页码：2095 / 2115

页数：21

共 50 条

[41] Pharmacological Improvement and Preclinical Evaluation of Methotrexate-Loaded Lipid-Core Nanocapsules in a Glioblastoma Model
Figueiro, Fabricio
de Oliveira, Catiuscia R.
Rockenbach, Liliana
Mendes, Franciane B.
Bergamin, Leticia S.
Jandrey, Elisa Helena F.
Edelweiss, Maria Isabel
Guterres, Silvia S.
Pohlmann, Adriana R.
Battastini, Ana Maria O.
JOURNAL OF BIOMEDICAL NANOTECHNOLOGY, 2015, 11 (10) : 1808 - 1818
[42] Application of ionic liquid to enhance the nose-to-brain delivery of etodolac
Tanigawa, Hiroaki
Suzuki, Naoto
Suzuki, Toyofumi
EUROPEAN JOURNAL OF PHARMACEUTICAL SCIENCES, 2022, 178
[43] Nose-to-brain transport of imatinib mesylate: A pharmacokinetic evaluation
Hada, Nobuko
Netzer, William Joseph
Belhassan, Fanny
Wennogle, Lawrence Paul
Gizurarson, Sveinbjorn
EUROPEAN JOURNAL OF PHARMACEUTICAL SCIENCES, 2017, 102 : 46 - 54
[44] Development and characterization of sorafenib-loaded lipid nanocapsules for the treatment of glioblastoma\
Clavreul, Anne
Roger, Emilie
Pourbaghi-Masouleh, Milad
Lemaire, Laurent
Tetaud, Clement
Menei, Philippe
DRUG DELIVERY, 2018, 25 (01) : 1756 - 1765
[45] Delivery of Brain-Derived Neurotrophic Factor via Nose-to-Brain Pathway
Vaka, Siva Ram Kiran
Murthy, Sathyanarayana Narasimha
Balaji, Anna
Repka, Michael A.
PHARMACEUTICAL RESEARCH, 2012, 29 (02) : 441 - 447
[46] NOSE-TO-BRAIN DRUG DELIVERY OF NANOFORMULATIONS: PREPARATION AND IN VITRO EVALUATION
Celikkol, Isik
Esim, Ozge
Hascicek, Canan
JOURNAL OF RESEARCH IN PHARMACY, 2023, 27
[47] Increased Nose-to-Brain Delivery of Melatonin Mediated by Polycaprolactone Nanoparticles for the Treatment of Glioblastoma
Edilson Ribeiro de Oliveira Junior
Thais Leite Nascimento
Mariana Arraes Salomão
Artur Christian Garcia da Silva
Marize Campos Valadares
Eliana Martins Lima
Pharmaceutical Research, 2019, 36
[48] Neuroprotective and Antioxidant Effect of Naringenin-Loaded Nanoparticles for Nose-to-Brain Delivery
Md, Shadab
Alhakamy, Nabil A.
Aldawsari, Hibah M.
Asfour, Hani Zakaria
BRAIN SCIENCES, 2019, 9 (10)
[49] Engineered dry powders for the nose-to-brain delivery of transforming growth factor-beta
Wong, Chun Yuen Jerry
Baldelli, Alberto
Gholizadeh, Hanieh
Oguzlu, Hale
Guo, Yigong
Ong, Hui Xin
Rodriguez, Athenea Pascal
Singuera, Gurpreet
Thamboo, Andrew
Singh, Anika
Pratap-Singh, Anubhav
Traini, Daniela
EUROPEAN JOURNAL OF PHARMACEUTICS AND BIOPHARMACEUTICS, 2023, 189 : 202 - 211
[50] An update on the role of nanovehicles in nose-to-brain drug delivery
Feng, Yunhai
He, Haisheng
Li, Fengqian
Lu, Yi
Qi, Jianping
Wu, Wei
DRUG DISCOVERY TODAY, 2018, 23 (05) : 1079 - 1088

← 1 2 3 4 5 →