Development of bozepinib-loaded nanocapsules for nose-to-brain delivery: preclinical evaluation in glioblastoma

被引：7
|
作者：
Dias, Amanda de Fraga [1 ]
Dallemole, Danieli Rosane [2 ]
Bruinsmann, Franciele Aline [2 ]
Lopes Silva, Luiz Fernando [1 ]
Cruz-Lopez, Olga [3 ,4 ]
Conejo-Garcia, Ana [3 ,4 ]
Oliveira Battastini, Ana Maria [1 ]
Maria Campos, Joaquin [3 ,4 ]
Guterres, Silvia Staniscuaski [2 ]
Pohlmann, Adriana Raffin [2 ]
Figueiro, Fabricio [1 ,5 ]
机构：
[1] Univ Fed Rio Grande do Sul, Inst Ciencias Basicas Saude, Programa Posgrad Ciencias Biol Bioquim, Porto Alegre, RS, Brazil
[2] Univ Fed Rio Grande do Sul, Fac Farm, Programa Posgrad Ciencias Farmaceut, Porto Alegre, RS, Brazil
[3] Fac Farm, Dept Quim Farmaceut & Organ, C Campus Cartuja S-N, Granada, Spain
[4] Inst Invest Biosanitaria Granada Ibs GRANADA, Granada, Spain
[5] Univ Fed Rio Grande do Sul, Inst Ciencias Basicas Saude, Dept Bioquim, Porto Alegre, RS, Brazil
来源：
NANOMEDICINE | 2021年 / 16卷 / 23期
关键词：
bozepinib; drug delivery; glioblastoma; intranasal; lipid-core nanocapsules; temozolomide; LIPID-CORE NANOCAPSULES; DRUG-DELIVERY; POLYMERIC NANOPARTICLES; INTRANASAL DELIVERY; EXPERIMENTAL-DESIGN; GROWTH-INHIBITION; IN-VITRO; CHITOSAN; COMBINATION; GLIOMA;
D O I：
10.2217/nnm-2021-0164
中图分类号：
Q81 [生物工程学（生物技术）]; Q93 [微生物学];
学科分类号：
071005 ; 0836 ; 090102 ; 100705 ;
摘要：
Aim: To develop and characterize bozepinib-loaded lipid-core nanocapsules (BZP-LNC+) as a potential treatment for glioblastoma (GBM). Methods: Characterization of nanocapsules was performed by diameter, polydispersity index, zeta potential, pH and encapsulation efficiency. GBM cell viability, cell cycle and Annexin/PI were evaluated after BZP-LNC+ treatment. Synergism between BZP-LNC+ and temozolomide (TMZ) was performed by CompuSyn software and confirmed in vitro and in vivo. Results: BZP-LNC+ showed adequate particle sizes, positive zeta potential, narrow size distribution and high encapsulation efficiency. BZP-LNC+ reduces GBM growth by inducing apoptosis. BZP-LNC+ and TMZ showed synergistic effect in vitro and reduced the in vivo glioma growth by approximately 81%. Conclusion: The present study provides proof-of-principle insights for the combination of these drugs for GBM treatment.
引用
收藏
页码：2095 / 2115
页数：21
相关论文
共 50 条
  • [1] Development of Atomoxetine-Loaded NLC In Situ Gel for Nose-to-Brain Delivery: Optimization, In Vitro, and Preclinical Evaluation
    Mohanty, Dibyalochan
    Alsaidan, Omar Awad
    Zafar, Ameeduzzafar
    Dodle, Trishala
    Gupta, Jeetendra Kumar
    Yasir, Mohd
    Mohanty, Anshuman
    Khalid, Mohammad
    PHARMACEUTICS, 2023, 15 (07)
  • [2] Nose-to-brain delivery of farnesylthiosalicylic acid loaded hybrid nanoparticles in the treatment of glioblastoma
    Sekerdag, E.
    Lule, S.
    Pehlivan, S. Bozdag
    Kara, A.
    Ozturk, N.
    Kaffashi, A.
    Vural, I.
    Yavuz, B.
    Oguz, K. Karli
    Soylemezoglu, F.
    Gursoy-Ozdemir, Y.
    Mut, M.
    JOURNAL OF THE NEUROLOGICAL SCIENCES, 2017, 381 : 171 - 172
  • [3] EGFRvIII peptide nanocapsules and bevacizumab nanocapsules: a nose-to-brain multitarget approach against glioblastoma
    de Cristo Soares Alves, Aline
    Lavayen, Vladimir
    de Fraga Dias, Amanda
    Bruinsmann, Franciele Aline
    Scholl, Juliete Nathali
    Ce, Rodrigo
    Visioli, Fernanda
    Oliveira Battastini, Ana Maria
    Staniscuaski Guterres, Silvia
    Figueiro, Fabricio
    Raffin Pohlmann, Adriana
    NANOMEDICINE, 2021, 16 (20) : 1775 - 1790
  • [4] Development of coated liposomes loaded with ghrelin for nose-to-brain delivery for the treatment of cachexia
    Salade, Laurent
    Wauthoz, Nathalie
    Deleu, Magali
    Vermeersch, Marjorie
    De Vriese, Carine
    Amighi, Karim
    Goole, Jonathan
    INTERNATIONAL JOURNAL OF NANOMEDICINE, 2017, 12 : 8531 - 8543
  • [5] Nose-to-Brain Delivery
    Wang, Zian
    Xiong, Guojun
    Tsang, Wai Chun
    Schatzlein, Andreas G.
    Uchegbu, Ijeoma F.
    JOURNAL OF PHARMACOLOGY AND EXPERIMENTAL THERAPEUTICS, 2019, 370 (03): : 593 - 601
  • [6] Nose-to-Brain Delivery
    Giunchedi, Paolo
    Gavini, Elisabetta
    Bonferoni, Maria Cristina
    PHARMACEUTICS, 2020, 12 (02)
  • [7] Development and evaluation of olanzapine-loaded PLGA nanoparticles for nose-to-brain delivery: In vitro and in vivo studies
    Seju, U.
    Kumar, A.
    Sawant, K. K.
    ACTA BIOMATERIALIA, 2011, 7 (12) : 4169 - 4176
  • [8] Nanosystems at Nexus: Navigating Nose-to-Brain Delivery for Glioblastoma Treatment
    Agnihotri, Tejas Girish
    Dahifale, Akanksha
    Gomte, Shyam Sudhakar
    Rout, Biswajit
    Peddinti, Vasu
    Jain, Aakanchha
    MOLECULAR PHARMACEUTICS, 2025, 22 (02) : 599 - 619
  • [9] Nose-to-Brain Delivery of Biomimetic Nanoparticles for Glioblastoma Targeted Therapy
    Ferreira, Natalia Noronha
    Leite, Celisnolia Morais
    Moreno, Natalia Sanchez
    Miranda, Renata Rank
    Lins, Paula Maria Pincela
    Rodero, Camila Fernanda
    de Oliveira Junior, Edilson
    Lima, Eliana Martins
    Reis, Rui M.
    Zucolotto, Valtencir
    ACS APPLIED MATERIALS & INTERFACES, 2024, 17 (01) : 484 - 499
  • [10] Nose-to-brain delivery of lamotrigine-loaded PLGA nanoparticles
    Nigam, Kuldeep
    Kaur, Atinderpal
    Tyagi, Amit
    Nematullah, Md
    Khan, Farah
    Gabrani, Reema
    Dang, Shweta
    DRUG DELIVERY AND TRANSLATIONAL RESEARCH, 2019, 9 (05) : 879 - 890
12345