Up-regulation of angiotensin-converting enzyme and angiotensin II type 1 receptor in irradiated rats

被引：14

作者：

Ferreira-Machado, Samara Cristina ^{[1
,2
,3
]}

Rocha, Nazareth De Novaes ^{[5
]}

Mencalha, Andre Luiz ^{[3
]}

Barbosa De Melo, Luiz Dione ^{[4
]}

Salata, Camila ^{[2
]}

Ribeiro, Andreia Fortes ^{[2
]}

Torres, Thiago Da Silva ^{[6
]}

Mandarim-De-Lacerda, Carlos Alberto ^{[6
]}

Canary, Paulo Cesar ^{[7
]}

De Freitas Peregrino, Antonio Augusto ^{[2
]}

Goncalves Magalhaes, Luis Alexandre ^{[2
]}

Cabral-Neto, Januario Bispo ^{[3
]}

Dealmeida, Carlos Eduardo ^{[2
]}

机构：

[1] Univ Fed Fluminense, Dept Biol Geral GBG, Lab Radiobiol & Radiomet, BR-24020140 Niteroi, RJ, Brazil

[2] Univ Fed Rio de Janeiro, Dept Biofis & Biomet, Lab Ciencias Radiol, Rio De Janeiro, Brazil

[3] Univ Fed Rio de Janeiro, CCS, Lab Controle Expressao Genica, Inst Biofis Carlos Chagas Filho, Rio De Janeiro, Brazil

[4] Univ Fed Fluminense, Inst Fed Educ Ciencia & Tecnol Rio de Janeiro, Genet Mol Lab, BR-24020140 Niteroi, RJ, Brazil

[5] Univ Fed Fluminense, Dept Fisiol & Farmacol, BR-24020140 Niteroi, RJ, Brazil

[6] Univ Fed Rio de Janeiro, Inst Biol, Lab Morfomet & Morfol Cardiovasc, Rio De Janeiro, Brazil

[7] Univ Fed Rio de Janeiro, Hosp Univ Clementino Fraga Filho, Serv Radioterapia, Fac Med,Dept Radiol, BR-21941 Rio De Janeiro, Brazil

来源：

INTERNATIONAL JOURNAL OF RADIATION BIOLOGY | 2010年 / 86卷 / 10期

关键词：

GROWTH-FACTOR-BETA; INDUCED HEART-DISEASE; LOCAL IONIZING IRRADIATION; MYOCARDIAL-INFARCTION; BREAST-CANCER; FIBROSIS; SYSTEM; ECHOCARDIOGRAPHY; FACTOR-BETA(1); RADIOTHERAPY;

D O I：

10.3109/09553002.2010.492489

中图分类号：

Q [生物科学];

学科分类号：

07 ; 0710 ; 09 ;

摘要：

Material and methods: Male Wistar rats were irradiated with a single dose of radiation (0, 5, 10 and 15 Gray [Gy]) delivered directly to the heart and the molecular evaluations were performed at various times post-irradiation (two days, 15 days and four months). The expression of ACE, AT1, proc-I and TGF-beta 1 were analysed using Real Time-Polymerase Chain Reaction (RT-PCR) and/or Western blotting. Cardiac structural and functional alterations were investigated at the four-month time point by echocardiography and by quantitative methods (stereology). Results: Rats irradiated with 15 Gy showed a modest reduction in the ejection fraction. Cardiac proc-I, TGF-beta 1, ACE and AT1 were also measurably increased. Conclusions: Irradiated rat hearts show simultaneous elevations in renin-angiotensin system components AT1 and ACE and cardiac remodeling markers proc-I and TGF-beta 1.

引用

页码：880 / 887

页数：8

共 32 条

[1] Electrical remodeling in the failing heart
Aiba, Takeshi
Tomaselli, Gordon F.
[J]. CURRENT OPINION IN CARDIOLOGY, 2010, 25 (01) : 29 - 36
[2] AJAY RB, 2006, AM J CLIN ONCOL-CANC, V29, P80
[3] Small molecular inhibitor of transforming growth factor-β protects against development of radiation-induced lung injury
Anscher, Mitchell S.
Thrasher, Bradley
Zgonjanin, Larisa
Rabbani, Zahid N.
Corbley, Michael J.
Fu, Kai
Sun, Lihong
Lee, Wen-Cherng
Ling, Leona E.
Vujaskovic, Zeljko
[J]. INTERNATIONAL JOURNAL OF RADIATION ONCOLOGY BIOLOGY PHYSICS, 2008, 71 (03): : 829 - 837
[4] Influence of mast cells on structural and functional manifestations of radiation-induced heart disease
Boerma, M
Wang, JR
Wondergem, J
Joseph, J
Qiu, XH
Kennedy, RH
Hauer-Jensen, M
[J]. CANCER RESEARCH, 2005, 65 (08) : 3100 - 3107
[5] Boerma M, 2004, STRAHLENTHER ONKOL, V180, P109, DOI 10.1007/s00066-004-1138-0
[6] Cardiac alterations in furosemide-treated thiamine-deprived rats
Da Cunha, Sergio
Bastos, Jayme Cunha
Salles, Joao Boscos
Silva, Maria Cristina Costa
Bastos, Vera Lucia Freire Cunha
Mandarim-De-Lacerda, Carlos Alberto
[J]. JOURNAL OF CARDIAC FAILURE, 2007, 13 (09) : 774 - 784
[7] Transforming Growth Factor-β Blockade Down-Regulates the Renin-Angiotensin System and Modifies Cardiac Remodeling after Myocardial Infarction
Ellmers, Leigh J.
Scott, Nicola J. A.
Medicherla, Satyanarayana
Pilbrow, Anna P.
Bridgman, Paul G.
Yandle, Timothy G.
Richards, A. Mark
Protter, Andrew A.
Cameron, Vicky A.
[J]. ENDOCRINOLOGY, 2008, 149 (11) : 5828 - 5834
[8] Angiotensin II increases collagen I expression via transforming growth factor-beta1 and extracellular signal-regulated kinase in cardiac fibroblasts
Gao, Xiuren
He, Xuyu
Luo, Bing
Peng, Longyun
Lin, Jun
Zuo, Zhiyi
[J]. EUROPEAN JOURNAL OF PHARMACOLOGY, 2009, 606 (1-3) : 115 - 120
[9] Cardiac complications of radiation therapy
Gaya, AM
Ashford, RFU
[J]. CLINICAL ONCOLOGY, 2005, 17 (03) : 153 - 159
[10] Risk of cardiac death after adjuvant radiotherapy for breast cancer
Giordano, SH
Kno, YF
Freeman, JL
Buchholz, TA
Hortobagyi, GN
Goodwin, JS
[J]. JNCI-JOURNAL OF THE NATIONAL CANCER INSTITUTE, 2005, 97 (06): : 419 - 424

← 1 2 3 4 →