Prophylaxis and treatment of acute lymphoblastic leukemia relapse after allogeneic hematopoietic stem cell transplantation

被引：7
作者：
Chen, Runzhe [1 ]
Campbell, Jos L. [2 ,3 ]
Chen, Baoan [1 ]
机构：
[1] Southeast Univ, Dept Hematol & Oncol, Zhongda Hosp, Key Dept Jiangsu Med,Med Sch, Nanjing 210009, Jiangsu, Peoples R China
[2] Stanford Univ, Dept Radiol, Mol Imaging Program Stanford, Palo Alto, CA 94304 USA
[3] RMIT Univ, Sch Appl Sci, Melbourne, Vic, Australia
来源：
ONCOTARGETS AND THERAPY | 2015年 / 8卷
关键词：
acute lymphoblastic leukemia; relapse; allogeneic hematopoietic stem cell transplantation; prevention; therapy; MINIMAL RESIDUAL DISEASE; VERSUS-HOST-DISEASE; DONOR LYMPHOCYTE INFUSION; BONE-MARROW-TRANSPLANTATION; ADULT PATIENTS; HIGH-RISK; PEDIATRIC-PATIENTS; UNRELATED DONORS; CHILDHOOD; CHILDREN;
D O I：
10.2147/OTT.S78567
中图分类号：
Q81 [生物工程学（生物技术）]; Q93 [微生物学];
学科分类号：
071005 ; 0836 ; 090102 ; 100705 ;
摘要：
Relapse of acute lymphoblastic leukemia remains a major cause of death in patients following allogeneic hematopoietic stem cell transplantation. Several factors may affect the concurrence and outcome of relapse, which include graft-versus-host disease, minimal residual disease or intrinsic factors of the disease, and transplantation characteristics. The mainstay of relapse prevention and treatment is donor leukocyte infusions, targeted therapies, second transplantation, and other novel therapies. In this review, we mainly focus on addressing the impact of graft-versus-host disease on relapse and the prophylaxis and treatment of acute lymphoblastic leukemia relapse following allogeneic hematopoietic stem cell transplantation. We also make recommendations for critical strategies to prevent relapse after transplantation and challenges that must be addressed to ensure success.
引用
收藏
页码：405 / 412
页数：8
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