Wound bed preparation for ischemic diabetic foot ulcer

Objective: This study is to evaluate the effect of allograft skin on wound angiogenesis and wound bed preparation of ischemic diabetic foot ulcer. Methods: A total of 60 cases of patients with diabetic foot ulcer were randomly divided into the experimental group (n = 30) and the control group (n = 30). After debridement, in the experimental group, allograft skin was used to cover the wound while in the control group, vaseline and gauze was used to cover the wound. The wound was opened and dressed at 3, 5, 7, 14 days after operation and the growth condition of the granulation tissue was observed and recorded. Results: The wound bed preparation time of the experimental group was 14.37 +/- 1.06 days, compared with the control group 25.99 +/- 4.03 days, there was statistically significant difference (t = 14.78, P < 0.0001). The mean cure time of the experimental group was 32 +/- 1.93 days and this time was significantly shortened than the control group 39.73 +/- 2.55 days (t = 12.521, P < 0.01). Conclusions: Allogeneic skin has a protective effect on the wound and could promote vascularization of ischemic diabetic foot ulcer and shorten the wound bed preparation time and treatment cycle.